小鼠蛛网膜下腔出血后迟发性神经功能缺损的发生率和因素

IF 1.3 Q4 CLINICAL NEUROLOGY
William Wroe , Ari Dienel , Sungha Hong , Kanako Matsumura , Jose Guzman , Kiara Torres , Angelica Bernal , Hussein A. Zeineddine , Peeyush Thankamani Pandit , Spiros L. Blackburn , Devin W. McBride
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引用次数: 0

摘要

目的延迟性脑缺血(DCI)是动脉瘤性蛛网膜下腔出血(SAH)最可怕的并发症之一。动物模型对于研究疾病机制和潜在治疗方法至关重要。啮齿类动物的DCI被认为是不存在的;在此,我们对文献和我们在啮齿类动物DCI方面的经验进行了研究。方法从SAH后第1天到最多7天,每天对5项不同研究中使用血管内穿孔模型的小鼠进行行为表现评估。小鼠的行为表现采用之前描述过的 8 次测试感觉运动神经评分法进行评分。然后使用每日神经评分来确定延迟性神经功能缺损 (DND) 的发生率和时间,DND 是 DCI 的临床替代指标。共有298只小鼠(雄性134只,雌性164只)接受了SAH治疗。结果 DND的总发生率为33.9%;雄性为27.6%,雌性为39.0%,但差异无统计学意义。延迟死亡的总发生率为 21.1%,雌性小鼠与雄性小鼠的延迟死亡率无显著差异。结论血管内穿刺诱发 SAH 的小鼠发生 DND 的比例与人类患者相当。未来的工作需要将DND与区域脑血流减少(DCI的另一个标志)联系起来,尽管有此需要,研究人员仍可利用小鼠模型来测试治疗SAH后DCI的疗法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Incidence and factors in delayed neurological deficits after subarachnoid hemorrhage in mice

Objective

Delayed cerebral ischemia (DCI) is one of the most feared complications in aneurysmal subarachnoid hemorrhage (SAH). Animal models are crucial to studying the disease mechanisms and potential treatments. DCI in rodents was thought to not exist; herein we examine literature and our experience with DCI in rodents.

Methods

Daily behavioral performance was assessed every day from day 1 to up to 7 days post-SAH on mice from 5 different studies that used the endovascular perforation model. Performance was graded using an 8-test sensorimotor neuroscore previously described. The daily neuroscore was then used to identify the incidence and timing of delayed neurological deficits (DND), a clinical surrogate for DCI. A total number of 298 mice (134 males, 164 females) were subjected to SAH. Fifty-one mice had histological staining done to identify infarct volume.

Results

The overall incidence of DND was 33.9%; 27.6% in males and 39.0% in females, but this difference was not statistically significant. The overall incidence of delayed death was 21.1%, and there was no significant difference for delayed mortality in females versus male mice. There is a non-statistically significant trend towards increased infarct volume in mice suffering DND.

Conclusions

Mice with endovascular puncture induced SAH develop DND at rates comparable to human patients. Future work needs to correlate the DND seen with decreased regional cerebral blood flow, another hallmark of DCI, but in spite of this need, researchers may use the murine models to test therapies for DCI after SAH.

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来源期刊
Brain Hemorrhages
Brain Hemorrhages Medicine-Surgery
CiteScore
2.90
自引率
0.00%
发文量
52
审稿时长
22 days
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