{"title":"癌症治疗对生殖健康的影响","authors":"Karolina Palinska-Rudzka, Cheryl Fitzgerald","doi":"10.1016/j.ogrm.2023.11.002","DOIUrl":null,"url":null,"abstract":"<div><p>Cancer treatments, including chemotherapy, surgery, and radiotherapy, present distinct challenges to reproductive health<span><span>. Ovarian function<span> might undergo various degrees of impairment, leading to a significantly diminished ovarian reserve<span>, even without persistent amenorrhea<span>. The return of menses post-chemotherapy might not mirror the full extend of follicular damage. Ovarian reserve testing is indicated in reproductive-aged cancer survivors. The magnitude of follicle depletion can be influenced by factors such as age, initial ovarian reserve, and specific treatment modalities. Radiotherapy, dependent on its target, can introduce risk to both ovarian and uterine health. Moreover, radiotherapy targeting the brain can disrupt the hypothalamic-pituitary-reproductive axis, adding another layer of reproductive complication. As </span></span></span></span>cancer survival rates improve, addressing these multifaceted reproductive concerns has become essential.</span></p></div>","PeriodicalId":53410,"journal":{"name":"Obstetrics, Gynaecology and Reproductive Medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of cancer treatment on reproductive health\",\"authors\":\"Karolina Palinska-Rudzka, Cheryl Fitzgerald\",\"doi\":\"10.1016/j.ogrm.2023.11.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Cancer treatments, including chemotherapy, surgery, and radiotherapy, present distinct challenges to reproductive health<span><span>. Ovarian function<span> might undergo various degrees of impairment, leading to a significantly diminished ovarian reserve<span>, even without persistent amenorrhea<span>. The return of menses post-chemotherapy might not mirror the full extend of follicular damage. Ovarian reserve testing is indicated in reproductive-aged cancer survivors. The magnitude of follicle depletion can be influenced by factors such as age, initial ovarian reserve, and specific treatment modalities. Radiotherapy, dependent on its target, can introduce risk to both ovarian and uterine health. Moreover, radiotherapy targeting the brain can disrupt the hypothalamic-pituitary-reproductive axis, adding another layer of reproductive complication. As </span></span></span></span>cancer survival rates improve, addressing these multifaceted reproductive concerns has become essential.</span></p></div>\",\"PeriodicalId\":53410,\"journal\":{\"name\":\"Obstetrics, Gynaecology and Reproductive Medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Obstetrics, Gynaecology and Reproductive Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1751721423001884\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Obstetrics, Gynaecology and Reproductive Medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1751721423001884","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
Effects of cancer treatment on reproductive health
Cancer treatments, including chemotherapy, surgery, and radiotherapy, present distinct challenges to reproductive health. Ovarian function might undergo various degrees of impairment, leading to a significantly diminished ovarian reserve, even without persistent amenorrhea. The return of menses post-chemotherapy might not mirror the full extend of follicular damage. Ovarian reserve testing is indicated in reproductive-aged cancer survivors. The magnitude of follicle depletion can be influenced by factors such as age, initial ovarian reserve, and specific treatment modalities. Radiotherapy, dependent on its target, can introduce risk to both ovarian and uterine health. Moreover, radiotherapy targeting the brain can disrupt the hypothalamic-pituitary-reproductive axis, adding another layer of reproductive complication. As cancer survival rates improve, addressing these multifaceted reproductive concerns has become essential.
期刊介绍：
Obstetrics, Gynaecology and Reproductive Medicine is an authoritative and comprehensive resource that provides all obstetricians, gynaecologists and specialists in reproductive medicine with up-to-date reviews on all aspects of obstetrics and gynaecology. Over a 3-year cycle of 36 issues, the emphasis of the journal is on the clear and concise presentation of information of direct clinical relevance to specialists in the field and candidates studying for MRCOG Part II. Each issue contains review articles on obstetric and gynaecological topics. The journal is invaluable for obstetricians, gynaecologists and reproductive medicine specialists, in their role as trainers of MRCOG candidates and in keeping up to date across the broad span of the subject area.
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