Plectranthus amboinicus (Lour.) Spreng 对氧化钾诱导的高尿酸血症小鼠的降尿酸功效

IF 0.7 4区农林科学 Q3 AGRONOMY

Emirates Journal of Food and Agriculture Pub Date : 2023-12-12 DOI:10.9755/ejfa.2023.3188

Chih-Chiang Wang, Chun Chen, Chih-Wei Chang, Po-Yen Chiu, Fu-An Chen

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引用次数: 0

摘要

Plectranthus amboinicus (Lour.) Spreng 是一种唇形科多年生草本植物，在民间被广泛用于治疗呼吸道疾病和皮肤病。值得注意的是，有关 P. amboinicus 降尿酸作用的研究还很有限。本研究通过体外黄嘌呤过氧化物酶抑制活性引导试验，研究了杏鲍菇提取物（PAE）及其馏分对氧化钾诱导的高尿酸血症小鼠的降尿酸作用。PAE的乙酸乙酯馏分（EAF）在酚含量、DPPH清除活性和黄嘌呤氧化酶抑制方面表现出最佳功效。我们还在溴酸钾诱导的高尿酸血症小鼠模型中进一步证实了 EAF 的降尿酸活性。这些结果可作为研究功能食品预防痛风作用的临床前参考。关键词藿香正气水高尿酸血症尿酸还原活性

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Uric acid–reducing efficacy of Plectranthus amboinicus (Lour.) Spreng in mice with potassium oxonate-induced hyperuricemia

Plectranthus amboinicus (Lour.) Spreng is a type of Lamiaceae perennial herb that is widely used in folk treatments for respiratory and skin diseases. Notably, research on the hypouricemic effect of P. amboinicus is limited. This study investigated the uric acid–reducing efficacy of P. amboinicus in mice with potassium oxonate-induced hyperuricemia by performing an in vitro xanthine-oxidase-inhibition-activity-guided test of P. amboinicus extract (PAE) and its fractions. The ethyl acetate fraction (EAF) of PAE exhibited optimal efficacy in terms of the phenolic content, DPPH scavenging activity, and xanthine oxidase inhibition. We further demonstrated the uric acid–reducing activity of EAF in a mouse model of potassium bromate–induced hyperuricemia. The results can serve as a useful preclinical reference for researching the gout prevention effects of functional foods. Keywords: Plectranthus amboinicus (Lour.) Spreng, hyperuricemia, uric acid–reducing activity

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来源期刊

Emirates Journal of Food and Agriculture AGRONOMYFOOD SCIENCE & TECHNOLOGY&nb-FOOD SCIENCE & TECHNOLOGY

CiteScore

1.80

自引率

0.00%

发文量

期刊介绍： The "Emirates Journal of Food and Agriculture [EJFA]" is a unique, peer-reviewed Journal of Food and Agriculture publishing basic and applied research articles in the field of agricultural and food sciences by the College of Food and Agriculture, United Arab Emirates University, United Arab Emirates.