伊拉克 2 型糖尿病患者的胰岛素抵抗、皮质醇激素和一些生化指标研究

Mohanad S. Al-Fayyadh, Kefah H. Ismael, Ali J.R.Al-Saady
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摘要

最常见的糖尿病类型是 2 型糖尿病。它是由于细胞无法识别胰岛素并对胰岛素做出反应,如果处理不当,会增加患病风险。这项研究旨在评估与 2 型糖尿病(T2D)患者血糖生成指数相关的一些生化变量。本研究从 37 名糖尿病(DM)患者中提取了某些生化指标。在本次研究中,对血脂、肾功能、胰岛素、糖化血红蛋白(HbA1c)、空腹血糖(FBS)、尿酸、胰岛素抵抗(HOMA-IR)和皮质醇激素进行了测量。37 名患者的血清取自亚尔穆克医院的糖尿病中心,27 名对照样本取自巴格达大学的健康人。 健康和非健康患者的年龄均为(19 至 47)岁。结果显示,与对照样本相比,糖尿病患者的 HbA1c、FBS、HOMA-IR、皮质醇、尿素、尿酸、血脂和肌酐水平较高,P≤0.05。本研究得出结论:血清皮质醇、FBS、HbA1c 和胰岛素水平异常升高。HOMA-IR的升高表明,IR是T2DM发生的一个危险因素。这项研究揭示了 T2DM 与肾功能参数之间的关系。研究发现,T2DM 患者的肌酐和尿素水平较高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Study of insulin resistance, cortisol hormone and some biochemical parameters in Iraqi type 2 diabetic patients
The most prevalent type of diabetes disease is type 2. It resulted through cells' failure for recognizing and responding to insulin, which can increase the risk of this disease  if improperly managed. This work seeks to assess  few biochemical variables connected to glycemic index in people  with type 2 diabetes (T2D). In this study, certain biochemical markers were taken from 37 patients with  diabetes mellitus (DM). In the current study,  lipid profile, kidney function, insulin, glycated hemoglobin (HbA1c), fasting blood sugar (FBS), uric acid, insulin resistance (HOMA-IR) and cortisol hormone were measured. The blood serum of the 37 patients were taken from diabetic center in Yarmouk hospital and 27 control sample were taken from healthy people  in the University of Baghdad.  The ages for healthy and unhealthy patients were (19 to 47 ) years old. The results showed that, diabetic participants had higher HbA1c, FBS, HOMA-IR, cortisol, urea, uric acid, lipid profile, and creatinine levels comparing to the control samples at P≤0.05. We concluded from this study, abnormally elevated levels of serum cortisol, FBS, HbA1c, and insulin. Increasing  HOMA-IR indicated  that IR is a risk factor for T2DM development. This work revealed a  relationship between T2DM and kidney function parameters. It was found that patients with T2D having higher levels of creatinine and urea.
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