在结直肠癌治疗中抗击核酸镰刀菌的新策略:系统回顾、改进和未来挑战

Hongyu Liu, Yunjian Yu, Alideertu Dong, Mahmoud Elsabahy, Ying-Wei Yang, Hui Gao
{"title":"在结直肠癌治疗中抗击核酸镰刀菌的新策略:系统回顾、改进和未来挑战","authors":"Hongyu Liu,&nbsp;Yunjian Yu,&nbsp;Alideertu Dong,&nbsp;Mahmoud Elsabahy,&nbsp;Ying-Wei Yang,&nbsp;Hui Gao","doi":"10.1002/EXP.20230092","DOIUrl":null,"url":null,"abstract":"<p>Colorectal cancer (CRC) is generally characterized by a high prevalence of <i>Fusobacterium nucleatum</i> (<i>F. nucleatum</i>), a spindle-shaped, Gram-negative anaerobe pathogen derived from the oral cavity. This tumor-resident microorganism has been closely correlated with the occurrence, progression, chemoresistance and immunosuppressive microenvironment of CRC. Furthermore, <i>F. nucleatum</i> can specifically colonize CRC tissues through adhesion on its surface, forming biofilms that are highly resistant to commonly used antibiotics. Accordingly, it is crucial to develop efficacious non-antibiotic approaches to eradicate <i>F. nucleatum</i> and its biofilms for CRC treatment. In recent years, various antimicrobial strategies, such as natural extracts, inorganic chemicals, organic chemicals, polymers, inorganic-organic hybrid materials, bacteriophages, probiotics, and vaccines, have been proposed to combat <i>F. nucleatum</i> and <i>F. nucleatum</i> biofilms. This review summarizes the latest advancements in anti-<i>F. nucleatum</i> research, elucidates the antimicrobial mechanisms employed by these systems, and discusses the benefits and drawbacks of each antimicrobial technology. Additionally, this review also provides an outlook on the antimicrobial specificity, potential clinical implications, challenges, and future improvements of these antimicrobial strategies in the treatment of CRC.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230092","citationCount":"0","resultStr":"{\"title\":\"Emerging strategies for combating Fusobacterium nucleatum in colorectal cancer treatment: Systematic review, improvements and future challenges\",\"authors\":\"Hongyu Liu,&nbsp;Yunjian Yu,&nbsp;Alideertu Dong,&nbsp;Mahmoud Elsabahy,&nbsp;Ying-Wei Yang,&nbsp;Hui Gao\",\"doi\":\"10.1002/EXP.20230092\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Colorectal cancer (CRC) is generally characterized by a high prevalence of <i>Fusobacterium nucleatum</i> (<i>F. nucleatum</i>), a spindle-shaped, Gram-negative anaerobe pathogen derived from the oral cavity. This tumor-resident microorganism has been closely correlated with the occurrence, progression, chemoresistance and immunosuppressive microenvironment of CRC. Furthermore, <i>F. nucleatum</i> can specifically colonize CRC tissues through adhesion on its surface, forming biofilms that are highly resistant to commonly used antibiotics. Accordingly, it is crucial to develop efficacious non-antibiotic approaches to eradicate <i>F. nucleatum</i> and its biofilms for CRC treatment. In recent years, various antimicrobial strategies, such as natural extracts, inorganic chemicals, organic chemicals, polymers, inorganic-organic hybrid materials, bacteriophages, probiotics, and vaccines, have been proposed to combat <i>F. nucleatum</i> and <i>F. nucleatum</i> biofilms. This review summarizes the latest advancements in anti-<i>F. nucleatum</i> research, elucidates the antimicrobial mechanisms employed by these systems, and discusses the benefits and drawbacks of each antimicrobial technology. Additionally, this review also provides an outlook on the antimicrobial specificity, potential clinical implications, challenges, and future improvements of these antimicrobial strategies in the treatment of CRC.</p>\",\"PeriodicalId\":72997,\"journal\":{\"name\":\"Exploration (Beijing, China)\",\"volume\":\"4 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-12-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230092\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Exploration (Beijing, China)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/EXP.20230092\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Exploration (Beijing, China)","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/EXP.20230092","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

大肠癌(CRC)通常以核不动杆菌(Fusobacterium nucleatum,F. nucleatum)的高发病率为特征,核不动杆菌是一种来自口腔的纺锤形革兰氏阴性厌氧菌病原体。这种肿瘤驻留微生物与 CRC 的发生、进展、化疗耐药性和免疫抑制微环境密切相关。此外,F. nucleatum 可通过粘附在 CRC 组织表面而特异性定植,形成对常用抗生素高度耐药的生物膜。因此,开发有效的非抗生素方法来根除 F. nucleatum 及其生物膜对治疗 CRC 至关重要。近年来,人们提出了各种抗菌策略,如天然提取物、无机化学品、有机化学品、聚合物、无机-有机杂化材料、噬菌体、益生菌和疫苗等,以对抗核酸酵母菌和核酸酵母菌生物膜。本综述总结了抗核不动杆菌研究的最新进展,阐明了这些系统所采用的抗菌机制,并讨论了每种抗菌技术的优点和缺点。此外,本综述还对治疗 CRC 的这些抗菌策略的抗菌特异性、潜在临床意义、挑战和未来改进进行了展望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Emerging strategies for combating Fusobacterium nucleatum in colorectal cancer treatment: Systematic review, improvements and future challenges

Emerging strategies for combating Fusobacterium nucleatum in colorectal cancer treatment: Systematic review, improvements and future challenges

Colorectal cancer (CRC) is generally characterized by a high prevalence of Fusobacterium nucleatum (F. nucleatum), a spindle-shaped, Gram-negative anaerobe pathogen derived from the oral cavity. This tumor-resident microorganism has been closely correlated with the occurrence, progression, chemoresistance and immunosuppressive microenvironment of CRC. Furthermore, F. nucleatum can specifically colonize CRC tissues through adhesion on its surface, forming biofilms that are highly resistant to commonly used antibiotics. Accordingly, it is crucial to develop efficacious non-antibiotic approaches to eradicate F. nucleatum and its biofilms for CRC treatment. In recent years, various antimicrobial strategies, such as natural extracts, inorganic chemicals, organic chemicals, polymers, inorganic-organic hybrid materials, bacteriophages, probiotics, and vaccines, have been proposed to combat F. nucleatum and F. nucleatum biofilms. This review summarizes the latest advancements in anti-F. nucleatum research, elucidates the antimicrobial mechanisms employed by these systems, and discusses the benefits and drawbacks of each antimicrobial technology. Additionally, this review also provides an outlook on the antimicrobial specificity, potential clinical implications, challenges, and future improvements of these antimicrobial strategies in the treatment of CRC.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
17.20
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信