慢性肾脏病(CKD)患者 NLRP3 炎症小体的作用和一些生化参数的评估

Nada Hussain Alwan, H. Faraj
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引用次数: 0

摘要

慢性肾脏病(CKD)是一种普遍存在的疾病,对人类健康构成重大威胁。随着公共卫生成本的大幅增加、严重的发病率和死亡率,慢性肾脏病的发病率也在不断上升。该研究旨在检测 NLRP3 炎症素组、hsCRP、尿素、肌酐、尿酸和 GFR 水平。研究测定了 90 名慢性肾脏病(CKD)患者和 85 名健康受试者的血清 NLRP3 炎症小体、hsCRP、尿素、肌酐、尿酸和 GFR 水平,受试者的年龄范围为 30-75 岁。目前的研究结果显示,与对照组相比,慢性肾脏病患者组的血清 NLRP3 炎性体、hs-CRP、尿素、肌酐和尿酸浓度明显增加(P<0.05)。与对照组相比,(CKD)患者组的 GRF 明显下降(P<0.05)。本研究旨在评估慢性肾脏病患者的 NLRP3 炎性体、炎症标志物、肾功能测试和肾小球滤过率(GFR)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Estimation of NLRP3 Inflammasome Role and some Biochemical Parameters in Patients with Chronic Kidney Diseases (CKD)
Chronic kidney disease (CKD) is a widespread condition that poses a major threat to human health. With substantial public health costs, severe morbidity, and mortality, CKD prevalence is increasing. The study aimed to look at NLRP3 inflammasome , hsCRP , Urea , Creatinine, Uric acid and GFR levels. Serum NLRP3 inflammasome , hsCRP , Urea , Creatinine, Uric acid and GFR levels were determined in 90 patients with Chronic Kidney Diseases (CKD) , and 85 healthy subjects, an age range (30-75). The results  of  current  study  show a significant increase in the concentration of serum NLRP3 inflammasome, hs-CRP, urea , creatinine and uric acid in (CKD) patients group in comparison with controls group (p<0.05). While shows a significant decrease in GRF in (CKD) patients group in comparison with controls group (p<0.05). The aim of this study is estimated the NLRP3 inflammasome ,  Inflammation marker ,  kidney function tests  and Glomerular  filtration rate (GFR)  in patients with Chronic Kidney Disease.
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