{"title":"慢性肾脏病(CKD)患者 NLRP3 炎症小体的作用和一些生化参数的评估","authors":"Nada Hussain Alwan, H. Faraj","doi":"10.32792/utq/utjsci/v10i2.1063","DOIUrl":null,"url":null,"abstract":"Chronic kidney disease (CKD) is a widespread condition that poses a major threat to human health. With substantial public health costs, severe morbidity, and mortality, CKD prevalence is increasing. The study aimed to look at NLRP3 inflammasome , hsCRP , Urea , Creatinine, Uric acid and GFR levels. Serum NLRP3 inflammasome , hsCRP , Urea , Creatinine, Uric acid and GFR levels were determined in 90 patients with Chronic Kidney Diseases (CKD) , and 85 healthy subjects, an age range (30-75). The results of current study show a significant increase in the concentration of serum NLRP3 inflammasome, hs-CRP, urea , creatinine and uric acid in (CKD) patients group in comparison with controls group (p<0.05). While shows a significant decrease in GRF in (CKD) patients group in comparison with controls group (p<0.05). The aim of this study is estimated the NLRP3 inflammasome , Inflammation marker , kidney function tests and Glomerular filtration rate (GFR) in patients with Chronic Kidney Disease.","PeriodicalId":23432,"journal":{"name":"University of Thi-Qar Journal of Science","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Estimation of NLRP3 Inflammasome Role and some Biochemical Parameters in Patients with Chronic Kidney Diseases (CKD)\",\"authors\":\"Nada Hussain Alwan, H. Faraj\",\"doi\":\"10.32792/utq/utjsci/v10i2.1063\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Chronic kidney disease (CKD) is a widespread condition that poses a major threat to human health. With substantial public health costs, severe morbidity, and mortality, CKD prevalence is increasing. The study aimed to look at NLRP3 inflammasome , hsCRP , Urea , Creatinine, Uric acid and GFR levels. Serum NLRP3 inflammasome , hsCRP , Urea , Creatinine, Uric acid and GFR levels were determined in 90 patients with Chronic Kidney Diseases (CKD) , and 85 healthy subjects, an age range (30-75). The results of current study show a significant increase in the concentration of serum NLRP3 inflammasome, hs-CRP, urea , creatinine and uric acid in (CKD) patients group in comparison with controls group (p<0.05). While shows a significant decrease in GRF in (CKD) patients group in comparison with controls group (p<0.05). The aim of this study is estimated the NLRP3 inflammasome , Inflammation marker , kidney function tests and Glomerular filtration rate (GFR) in patients with Chronic Kidney Disease.\",\"PeriodicalId\":23432,\"journal\":{\"name\":\"University of Thi-Qar Journal of Science\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-12-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"University of Thi-Qar Journal of Science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.32792/utq/utjsci/v10i2.1063\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"University of Thi-Qar Journal of Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32792/utq/utjsci/v10i2.1063","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Estimation of NLRP3 Inflammasome Role and some Biochemical Parameters in Patients with Chronic Kidney Diseases (CKD)
Chronic kidney disease (CKD) is a widespread condition that poses a major threat to human health. With substantial public health costs, severe morbidity, and mortality, CKD prevalence is increasing. The study aimed to look at NLRP3 inflammasome , hsCRP , Urea , Creatinine, Uric acid and GFR levels. Serum NLRP3 inflammasome , hsCRP , Urea , Creatinine, Uric acid and GFR levels were determined in 90 patients with Chronic Kidney Diseases (CKD) , and 85 healthy subjects, an age range (30-75). The results of current study show a significant increase in the concentration of serum NLRP3 inflammasome, hs-CRP, urea , creatinine and uric acid in (CKD) patients group in comparison with controls group (p<0.05). While shows a significant decrease in GRF in (CKD) patients group in comparison with controls group (p<0.05). The aim of this study is estimated the NLRP3 inflammasome , Inflammation marker , kidney function tests and Glomerular filtration rate (GFR) in patients with Chronic Kidney Disease.