Norbaiyah Mohamed Bakrim, Wan Fatein Nabeila Wan Omar, Aszrin Abdullah, Nurul Nadiah Hamidon, Suhaila Abdul Muid, Aisyah Badrulhisham
{"title":"血浆aptoglobin作为年轻高血压成人冠状动脉疾病的潜在生物标记物","authors":"Norbaiyah Mohamed Bakrim, Wan Fatein Nabeila Wan Omar, Aszrin Abdullah, Nurul Nadiah Hamidon, Suhaila Abdul Muid, Aisyah Badrulhisham","doi":"10.31436/imjm.v23i01.2371","DOIUrl":null,"url":null,"abstract":"INTRODUCTION: Uncontrolled hypertension is one of the recognized risk factors for coronary artery disease (CAD) in young adults, commonly underestimated owing to the young age. A novel biomarker to improve CAD risk assessment and hypertension management should be identified for this cohort. Thus, we had conducted a study to investigate plasma concentration and the role of haptoglobin in young hypertensive adults in the establishment of premature acute myocardial infarction (AMI). MATERIALS AND METHODS: A total of 120 male adults aged between 18 to 45 years enrolled into this cross-sectional study, divided into control, hypertensive, and acute myocardial infarction (AMI) groups. Blood samples were collected from all subjects, plasma concentrations of haptoglobin measured using enzyme-linked immunosorbent assays, and other CAD risk factors including high sensitivity C-reactive protein (hs-CRP) levels were analyzed. RESULTS: Plasma concentration of haptoglobin in the AMI group was the highest compared to hypertensive and control group (290.63±99.90 vs. 208.47±112.93 vs. 170.02±108.11 ng/ml, p<0.006). There was a significant association between AMI and plasma haptoglobin concentration in hypertensive subjects independent of other known CAD risk factors (OR: 0.985, 95% CI 0.973-0.997, p=0.017). There was positive correlation between plasma haptoglobin and hs-CRP (r=0.0370, p<0.001). CONCLUSION: Plasma haptoglobin is a potential biomarker to identify young hypertensive adults who are at risk of developing CAD.","PeriodicalId":13474,"journal":{"name":"IIUM Medical Journal Malaysia","volume":"49 11","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Plasma Haptoglobin as A Potential Biomarker for Coronary Artery Disease in Young Hypertensive Adults\",\"authors\":\"Norbaiyah Mohamed Bakrim, Wan Fatein Nabeila Wan Omar, Aszrin Abdullah, Nurul Nadiah Hamidon, Suhaila Abdul Muid, Aisyah Badrulhisham\",\"doi\":\"10.31436/imjm.v23i01.2371\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"INTRODUCTION: Uncontrolled hypertension is one of the recognized risk factors for coronary artery disease (CAD) in young adults, commonly underestimated owing to the young age. A novel biomarker to improve CAD risk assessment and hypertension management should be identified for this cohort. Thus, we had conducted a study to investigate plasma concentration and the role of haptoglobin in young hypertensive adults in the establishment of premature acute myocardial infarction (AMI). MATERIALS AND METHODS: A total of 120 male adults aged between 18 to 45 years enrolled into this cross-sectional study, divided into control, hypertensive, and acute myocardial infarction (AMI) groups. Blood samples were collected from all subjects, plasma concentrations of haptoglobin measured using enzyme-linked immunosorbent assays, and other CAD risk factors including high sensitivity C-reactive protein (hs-CRP) levels were analyzed. RESULTS: Plasma concentration of haptoglobin in the AMI group was the highest compared to hypertensive and control group (290.63±99.90 vs. 208.47±112.93 vs. 170.02±108.11 ng/ml, p<0.006). There was a significant association between AMI and plasma haptoglobin concentration in hypertensive subjects independent of other known CAD risk factors (OR: 0.985, 95% CI 0.973-0.997, p=0.017). There was positive correlation between plasma haptoglobin and hs-CRP (r=0.0370, p<0.001). CONCLUSION: Plasma haptoglobin is a potential biomarker to identify young hypertensive adults who are at risk of developing CAD.\",\"PeriodicalId\":13474,\"journal\":{\"name\":\"IIUM Medical Journal Malaysia\",\"volume\":\"49 11\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"IIUM Medical Journal Malaysia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.31436/imjm.v23i01.2371\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"IIUM Medical Journal Malaysia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31436/imjm.v23i01.2371","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
导言:未控制的高血压是公认的青壮年冠状动脉疾病(CAD)风险因素之一,由于年龄较小,通常被低估。应该为这一人群找到一种新的生物标志物,以改善 CAD 风险评估和高血压管理。因此,我们开展了一项研究,以调查血红蛋白在年轻高血压成人中的血浆浓度及其在早发急性心肌梗死(AMI)中的作用。材料和方法:共有 120 名年龄在 18 至 45 岁之间的男性成年人参加了这项横断面研究,分为对照组、高血压组和急性心肌梗死(AMI)组。研究人员采集了所有受试者的血样,使用酶联免疫吸附测定法测量了血红蛋白的血浆浓度,并分析了包括高敏C反应蛋白(hs-CRP)水平在内的其他CAD风险因素。结果:与高血压组和对照组相比,AMI 组血浆中的高铁血红蛋白浓度最高(290.63±99.90 vs. 208.47±112.93 vs. 170.02±108.11 ng/ml,P<0.006)。高血压受试者的急性心肌梗死与血浆高铁血红蛋白浓度之间存在明显关联,与其他已知的冠状动脉粥样硬化风险因素无关(OR:0.985,95% CI 0.973-0.997,P=0.017)。血浆血红蛋白与 hs-CRP 呈正相关(r=0.0370,p<0.001)。结论:血浆高铁血红蛋白是一种潜在的生物标志物,可用于识别有患 CAD 风险的年轻高血压成人。
Plasma Haptoglobin as A Potential Biomarker for Coronary Artery Disease in Young Hypertensive Adults
INTRODUCTION: Uncontrolled hypertension is one of the recognized risk factors for coronary artery disease (CAD) in young adults, commonly underestimated owing to the young age. A novel biomarker to improve CAD risk assessment and hypertension management should be identified for this cohort. Thus, we had conducted a study to investigate plasma concentration and the role of haptoglobin in young hypertensive adults in the establishment of premature acute myocardial infarction (AMI). MATERIALS AND METHODS: A total of 120 male adults aged between 18 to 45 years enrolled into this cross-sectional study, divided into control, hypertensive, and acute myocardial infarction (AMI) groups. Blood samples were collected from all subjects, plasma concentrations of haptoglobin measured using enzyme-linked immunosorbent assays, and other CAD risk factors including high sensitivity C-reactive protein (hs-CRP) levels were analyzed. RESULTS: Plasma concentration of haptoglobin in the AMI group was the highest compared to hypertensive and control group (290.63±99.90 vs. 208.47±112.93 vs. 170.02±108.11 ng/ml, p<0.006). There was a significant association between AMI and plasma haptoglobin concentration in hypertensive subjects independent of other known CAD risk factors (OR: 0.985, 95% CI 0.973-0.997, p=0.017). There was positive correlation between plasma haptoglobin and hs-CRP (r=0.0370, p<0.001). CONCLUSION: Plasma haptoglobin is a potential biomarker to identify young hypertensive adults who are at risk of developing CAD.