炎症标志物与体质虚弱:走向临床应用。

IF 5.2 2区 医学 Q1 GERIATRICS & GERONTOLOGY
Yiming Pan, Lina Ma
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引用次数: 0

摘要

全球人口老龄化给全世界的医疗保健系统带来了巨大负担。虚弱与体力储备下降有关,被认为是老年人口不良事件的一个重要指标。因此,人们对虚弱的早期诊断和干预越来越感兴趣,但造成虚弱的细胞机制仍未完全明了。慢性炎症与身体功能下降和疾病风险增加有关。此外,多项人类和动物研究表明,炎症可能是导致虚弱的最大因素。一些炎症标志物已被用于预测身体虚弱。然而,这些标志物在体弱患者中的临床应用仍存在很大的知识差距。因此,了解其生物学过程并确定公认可靠的标志物是老年病学家的紧迫而关键的任务。在本综述中,我们广泛总结了可能具有潜在诊断和治疗用途的炎症标志物,从而在不久的将来将其转化为老年虚弱患者的医疗保健。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Inflammatory markers and physical frailty: towards clinical application.

Global population aging poses a tremendous burden on the health care system worldwide. Frailty is associated with decreased physical reserve and is considered an important indicator of adverse events in the older population. Therefore, there is growing interest in the early diagnosis and intervention of frailty, but the cellular mechanisms responsible for frailty are still not completely understood. Chronic inflammation is related to decreased physical function and increased disease risk. Additionally, multiple human and animal studies suggest that inflammation probably plays the largest role in contributing to frailty. Some inflammatory markers have been proposed to predict physical frailty. However, there are still large gaps in knowledge related to the clinical application of these markers in frail patients. Therefore, understanding the biological processes and identifying recognized and reliable markers are urgent and pivotal tasks for geriatricians. In the present review, we broadly summarize the inflammatory markers that may have potential diagnostic and therapeutic use, thereby translating them into health care for older people with frailty in the near future.

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来源期刊
Immunity & Ageing
Immunity & Ageing GERIATRICS & GERONTOLOGY-IMMUNOLOGY
CiteScore
10.20
自引率
3.80%
发文量
55
期刊介绍: Immunity & Ageing is a specialist open access journal that was first published in 2004. The journal focuses on the impact of ageing on immune systems, the influence of aged immune systems on organismal well-being and longevity, age-associated diseases with immune etiology, and potential immune interventions to increase health span. All articles published in Immunity & Ageing are indexed in the following databases: Biological Abstracts, BIOSIS, CAS, Citebase, DOAJ, Embase, Google Scholar, Journal Citation Reports/Science Edition, OAIster, PubMed, PubMed Central, Science Citation Index Expanded, SCImago, Scopus, SOCOLAR, and Zetoc.
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