大气环境与小儿哮喘的持续性:一项基于人群的队列研究。

IF 2.3 4区 医学 Q3 ALLERGY
Hwan Soo Kim, Kyunghoon Kim, Eun Hee Rhee, Woo Kyung Kim, Dae Jin Song, Ji Soo Park, Dong In Suh, Jisun Yoon, Eun Lee, Seung Won Lee, Jin Tack Kim, Dae Hyun Lim, Hey Sung Baek, Meeyong Shin, Ji Won Kwon, Gwang Cheon Jang, Ju Hee Seo, Sung Il Woo, Hyung Young Kim, Ju Suk Lee, Young Yoo Yoo
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引用次数: 0

摘要

背景:哮喘是一种异质性疾病,其治疗效果各不相同。7岁时患有哮喘的儿童中,67%-75%在成年后无症状。有关儿童哮喘与成人哮喘之间重要联系的数据却很少:我们旨在通过将韩国儿童哮喘研究(KAS)的数据与健康保险审查和评估服务(HIRA)的匹配索赔数据联系起来,调查与儿童哮喘在三年随访期间持续存在有关的因素:我们分析了450名7至10岁青春期前儿童的数据,并将他们分为缓解组和持续组。比较了基线临床特征和三年随访期间接触空气污染物质(包括 PM2.5 和 PM10)的情况。主要结果是哮喘持续状态,即在 KAS 注册后三年内出现哮喘发作并使用医疗服务和开具哮喘药物处方:在随访的第三年,经过逐步回归分析,较低的入学年龄(调整赔率(aOR):0.79;95% 置信区间(CI):0.64-0.96)、男性(aOR:1.66;95%CI:1.05-2.63)、距离空气污染设施较近(aOR:2.4;95%CI:1.34-4.29)、较高的室外 PM2.5(aOR:1.1;95%CI:1.02-1.20)和较高的医生诊断食物过敏(FA)率(aOR:2.33;95%CI:1.06-5.12)与持续性显著相关:结论:我们发现了儿童哮喘持续存在的各种独立风险因素。结论:我们发现了导致儿童哮喘持续存在的各种独立风险因素。通过将 HIRA 索赔数据联系起来,我们可以在一个定义明确的研究人群中明确导致哮喘持续存在的风险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Atmospheric environment and persistence of pediatric asthma: A population-based cohort study.

Background: Asthma is a heterogeneous disease with different outcomes. For children with asthma at the age of 7 years, 67-75% are symptom-free as adults. Data on the important link between childhood and adult asthma are sparse.

Objective: We aimed to investigate factors associated with persistence of childhood asthma over three years of follow-up by linking data between Korea childhood Asthma Study (KAS) and their matched claims data from Health Insurance Review and Assessment Service (HIRA).

Methods: We analyzed data from 450 preadolescent children aged 7 to 10 years and classified them into remission or persistence groups. Baseline clinical characteristics and exposure to air pollution materials including PM2.5 and PM10 during three years of follow-up were compared. The main outcome was asthma persistence which was defined as the presence of asthma episodes with healthcare utilization and prescription of asthma medications within three years after KAS enrollment.

Results: At the third year of follow-up, after stepwise regression analysis, lower age at enrollment (adjusted odds ratio (aOR): 0.79; 95% confidence interval (CI): 0.64-0.96), male sex (aOR: 1.66; 95%CI: 1.05-2.63), proximity from an air-polluting facility (aOR: 2.4; 95%CI: 1.34-4.29), higher level outdoor PM2.5 (aOR: 1.1; 95%CI: 1.02-1.20), and higher rate of doctor-diagnosed food allergy (FA) (aOR: 2.33; 95%CI: 1.06-5.12) were significantly associated with persistence.

Conclusion: We discovered various independent risk factors for the persistence of childhood asthma. By linking HIRA claims data, we could clarify risk factors for persistence in a well-defined study population.

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来源期刊
CiteScore
12.80
自引率
0.00%
发文量
74
审稿时长
>12 weeks
期刊介绍: The Asian Pacific Journal of Allergy and Immunology (APJAI) is an online open access journal with the recent impact factor (2018) 1.747 APJAI published 4 times per annum (March, June, September, December). Four issues constitute one volume. APJAI publishes original research articles of basic science, clinical science and reviews on various aspects of allergy and immunology. This journal is an official journal of and published by the Allergy, Asthma and Immunology Association, Thailand. The scopes include mechanism, pathogenesis, host-pathogen interaction, host-environment interaction, allergic diseases, immune-mediated diseases, epidemiology, diagnosis, treatment and prevention, immunotherapy, and vaccine. All papers are published in English and are refereed to international standards.
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