将振动作为体内研究的外部变量进行评估。

Randall P Reynolds, John N Norton
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引用次数: 0

摘要

由于动物护理和使用所需的机械系统和操作方法,振动是研究动物设施中固有的现象。大量证据表明,振动会改变多个物种的行为和生理,从而可能改变研究结果。虽然我们无法消除环境振动,但在研究动物的环境中控制振动非常重要,这样可以减少因振动影响而引入研究变量的可能性。要评估振动源改变实验结果和变异性的可能性,必须了解振动原理、可能的振动源和控制方法。由于迄今为止测试的振动频率往往不在或接近被测物种的最敏感范围内,因此有关振动影响的文献在实际应用中很难解释。以前的一些研究使用了不切实际的振动幅度,并且没有提供足够的细节来重复或建立结论。标准化对于研究振动对动物的影响至关重要,它可以验证动物研究中这一外在变量的知识,并确定在研究设施中减轻该变量的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of Vibration as an Extrinsic Variable in In Vivo Research.

Vibration is inherent in research animal facilities due to the mechanical systems and practices required for animal care and use. Ample evidence indicates that vibration can change behavior and physiology in multiple species, potentially altering the results of research studies. Although one cannot eliminate environmental vibration, its control is important in research animal environments to decrease the possibility of introducing a research variable due to vibration effects. To assess the potential for a vibration source to alter experimental results and variability, one must understand the principles of vibration, its likely sources, and control methods. The literature regarding the effects of vibration, as it applies in a practical sense, can be challenging to interpret because the vibration frequencies tested to date have often not been within or near the most sensitive ranges of the species being tested. Some previous studies have used unrealistic vibration magnitudes and provided insufficient detail to duplicate or build upon conclusions. Standardization is essential for research examining the effects of vibration on animals to validate knowledge of this extrinsic variable in animal research and identify ways to mitigate the variable in research facilities.

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