一名晚期癌症患者的多重用药和可逆药物诱发的 QT 间期延长:病例报告。

IF 0.9 Q3 ANESTHESIOLOGY
Gabriela Cerdà, Joaquim Julià-Torras, Jesús González-Barboteo, Margarita Romeo, Agnès Calsina-Berna
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引用次数: 0

摘要

QT 延长与室性心律失常的发生有关,如可导致心脏性猝死的 Torsade de Pointes(TdP)。用于治疗晚期癌症患者的几种药物可能会因干扰心脏离子通道而诱发 QT 间期延长。如果存在易感因素,一些患者的风险可能会更高。在此,我们介绍了一例正在接受根治性抗肿瘤治疗的晚期癌症患者,该患者在同时接受美沙酮、氟哌啶醇和氟西汀治疗时,出现了可逆的药物诱导 QT 间期延长,并伴有胸痛和心动过缓。本文讨论了针对有药物诱发 QT 间期延长风险的癌症患者的治疗方法,强调了对患者进行全面用药检查的必要性,并特别强调了对使用多种药物的患者进行用药检查的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Polypharmacy and Reversible Drug Induced QT Prolongation in a Patient with Advanced Cancer: Case Report.

QT prolongation is related to the development of ventricular arrhythmias such as Torsade de Pointes (TdP) that can lead to sudden cardiac death. Several drugs used in the treatment of patients with advanced cancer may induce QT prolongation due to their interference with cardiac ion channels. Some patients may be at higher risk if predisposing factors are present. Herein we present the case of a patient with advanced cancer under anti-tumor treatment with radical intention that developed a reversible drug-induced QT prolongation when simultaneously treated with methadone, haloperidol and fluoxetine that presented with chest pain and bradycardia. An approach to cancer patients at risk for drug-induced QT prolongation is discussed highlighting the need of a thorough medication review with a special focus in the patient with polypharmacy.

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来源期刊
CiteScore
1.60
自引率
9.10%
发文量
40
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