后 COVID-19 患者肠道微生物群的改变及其与免疫功能的关系。

IF 2.4 4区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Folia microbiologica Pub Date : 2024-08-01 Epub Date: 2024-01-05 DOI:10.1007/s12223-023-01118-z
Jiaojiao Cai, Jingru Xu, Yan Tan, Yao Xiang, Zhifeng Li, Juan Zheng, Yingli Li
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引用次数: 0

摘要

为了揭示已治愈的冠状病毒2019(COVID-19)患者肠道微生物群的变异及其与免疫功能的关系,我们通过高通量16S rRNA测序分析了出院20~23个月的患者和健康志愿者的肠道微生物群。结果显示,COVID-19 疾病患者肠道微生物中 6 个微生物属的含量发生了变化,且比例高于 0.1%:Subdoligranulum、嗜血杆菌、Coprococcus、Eubacterium vertriosum 组和 Lachnospiraceae ND3007 组的含量减少,而 Hungatella 的含量增加。NK 细胞与 Subdoligranulum 呈负相关,而 CD8 细胞与 Subdoligranulum 呈正相关,但与 Hungatella 呈负相关。IL-8浓度与亚多利格兰菌、嗜血杆菌、铜绿假单胞菌、疣状大肠杆菌群和拉氏菌ND3007群呈负相关,但与Hungatella呈正相关;IL-1β浓度与嗜血杆菌和通风大肠杆菌群呈负相关,但与Hungatella呈正相关。益生菌和潜在致病菌的差异意味着疾病和炎症的风险较高,而肠道微生物群的调节可能有助于 COVID-19 患者的康复。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Gut microbiota alteration and its association with immune function in post-COVID-19 patients.

Gut microbiota alteration and its association with immune function in post-COVID-19 patients.

To reveal the variation of gut microbiota and its association with immune function in cured patients with coronavirus 2019 (COVID-19) disease, gut microbiota of patients discharged from hospital for 20 ~ 23 months and healthy volunteers was analyzed by high throughput 16S rRNA sequencing. The diversity and abundance were compared, and the correlation with immunity factors was investigated, and changes in the content of 6 genera microorganisms with proportion higher than 0.1% were revealed in patients with COVID-19 disease: reduced content of Subdoligranulum, Haemophilus, Coprococcus, Eubacterium vertriosum group, and Lachnospiraceae ND3007 group and increased content of Hungatella. NK cells were negatively correlated to Subdoligranulum, while CD8 cells were positively correlated to Subdoligranulum but negative to Hungatella. IL-8 concentration was negatively correlated to Subdoligranulum, Haemophilus, Coprococcus, Eubacterium vertriosum group, and Lachnospiraceae ND3007 group but positively to Hungatella, while IL-1β concentration was negatively correlated to Haemophilus and Eubacterium ventriosum group but positively to Hungatella. The variation of probiotics and potential pathogenic bacteria implies a higher risk in diseases and inflammation, and the modulation of the gut microbiota may help the healing of COVID-19 patients.

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来源期刊
Folia microbiologica
Folia microbiologica 工程技术-生物工程与应用微生物
CiteScore
5.80
自引率
0.00%
发文量
82
审稿时长
6-12 weeks
期刊介绍: Unlike journals which specialize ever more narrowly, Folia Microbiologica (FM) takes an open approach that spans general, soil, medical and industrial microbiology, plus some branches of immunology. This English-language journal publishes original papers, reviews and mini-reviews, short communications and book reviews. The coverage includes cutting-edge methods and promising new topics, as well as studies using established methods that exhibit promise in practical applications such as medicine, animal husbandry and more. The coverage of FM is expanding beyond Central and Eastern Europe, with a growing proportion of its contents contributed by international authors.
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