细胞斯巴达人的关口:肿瘤早期和晚期细胞竞争的新奥秘

IF 6 2区 生物学 Q1 CELL BIOLOGY
Carlos Fernández Moro , Natalie Geyer , Marco Gerling
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引用次数: 0

摘要

细胞竞争是一种基于细胞间适应性比较的细胞质量控制机制。最近的研究揭示了细胞竞争在癌症中的核心和复杂作用。早期肿瘤利用细胞竞争取代邻近的正常上皮细胞。例如,肠腺瘤利用细胞竞争来取代野生型上皮细胞。然而,致癌突变并不总能带来优势:野生型细胞可以识别突变细胞,并通过细胞竞争将其挤出,这一过程被称为 "上皮细胞抗癌防御"。在转移过程中出现了一种特别有趣的情况:具有超强竞争力的肿瘤细胞遇到异型伙伴,进行相互竞争,结果却各不相同。本文通过重点介绍揭示细胞竞争环境依赖性的最新研究,揭示了细胞竞争的复杂性。最后,我们提出组织形态学意味着细胞竞争在肿瘤侵袭前沿,尤其是在转移瘤中发挥着至关重要的作用,值得在未来的研究中给予更多关注。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cellular spartans at the pass: Emerging intricacies of cell competition in early and late tumorigenesis

Cell competition is a mechanism for cellular quality control based on cell–cell comparisons of fitness. Recent studies have unveiled a central and complex role for cell competition in cancer. Early tumors exploit cell competition to replace neighboring normal epithelial cells. Intestinal adenomas, for example, use cell competition to outcompete wild-type epithelial cells. However, oncogenic mutations do not always confer an advantage: wild-type cells can identify mutant cells and enforce their extrusion through cell competition, a process termed “epithelial defense against cancer”. A particularly interesting situation emerges in metastasis: supercompetitive tumor cells encounter heterotypic partners and engage in reciprocal competition with diverging outcomes. This article sheds light on the emerging complexity of cell competition by highlighting recent studies that unveil its context dependency. Finally, we propose that tissue histomorphology implies a crucial role for cell competition at tumor invasion fronts particularly in metastases, warranting increased attention in future studies.

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来源期刊
Current Opinion in Cell Biology
Current Opinion in Cell Biology 生物-细胞生物学
CiteScore
14.60
自引率
1.30%
发文量
79
审稿时长
93 days
期刊介绍: Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.
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