牵引细胞集体中的固液相变

IF 6 2区 生物学 Q1 CELL BIOLOGY
Diana Pinheiro , Jennifer Mitchel
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引用次数: 0

摘要

细胞集体必须动态地适应不同的生物环境。例如,在平衡状态下,上皮细胞必须在身体各部分之间建立屏障并抵御外部压力,而在发育、伤口愈合或癌症侵袭期间,这些组织则会经历广泛的重塑。利用惰性、被动材料的类比,细胞密度、形状、重新排列和/或迁移的变化被证明会导致固态和流态之间的集体转变。然而,这些转变受何种生物机制支配仍是一个悬而未决的问题。特别是,控制决定组织流变学和动力学的关键物理轴的上游信号通路和分子效应器仍然鲜为人知。在这一视角中,我们重点关注新出现的证据,这些证据确定了决定活体组织集体状态的第一种生物信号,并强调了这些机制是如何在不同的生物环境中发挥功能的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pulling the strings on solid-to-liquid phase transitions in cell collectives

Cell collectives must dynamically adapt to different biological contexts. For instance, in homeostatic conditions, epithelia must establish a barrier between body compartments and resist external stresses, while during development, wound healing or cancer invasion, these tissues undergo extensive remodeling. Using analogies from inert, passive materials, changes in cellular density, shape, rearrangements and/or migration were shown to result in collective transitions between solid and fluid states. However, what biological mechanisms govern these transitions remains an open question. In particular, the upstream signaling pathways and molecular effectors controlling the key physical axes determining tissue rheology and dynamics remain poorly understood. In this perspective, we focus on emerging evidence identifying the first biological signals determining the collective state of living tissues, with an emphasis on how these mechanisms are exploited for functionality across biological contexts.

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来源期刊
Current Opinion in Cell Biology
Current Opinion in Cell Biology 生物-细胞生物学
CiteScore
14.60
自引率
1.30%
发文量
79
审稿时长
93 days
期刊介绍: Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.
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