幽门螺杆菌和奥沙西汀对β-内酰胺对耐甲氧西林金黄色葡萄球菌的增效作用

IF 2.1 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Journal of Antibiotics Pub Date : 2024-01-04 DOI:10.1038/s41429-023-00691-2

Masako Honsho, Aoi Kimishima, Akari Ikeda, Masato Iwatsuki, Kenichi Nonaka, Hidehito Matsui, Hideaki Hanaki, Yukihiro Asami, Toshiaki Sunazuka

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引用次数: 0

摘要

抗菌药耐药性（AMR）对全球健康构成威胁，给人类造成巨大损失。其中，对美罗培南（MEPM）等一线治疗用β-内酰胺类药物产生耐药性的耐甲氧西林金黄色葡萄球菌（MRSA）是一个难题。因此，我们将重点放在联合用药治疗上，并一直在寻找新的美罗培南增效剂来对抗 MRSA。在本文中，我们报告了从新阴孢子虫 FKI-8547 菌株的培养液中分离出的phomoidrides A-D 及其新类似物 phomoidride H 以及一种多酮化合物 oxasetin，作为 MEPM 对抗 MRSA 的增效剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The potentiation activity of β-lactam by phomoidrides and oxasetin against methicillin-resistant Staphylococcus aureus

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The potentiation activity of β-lactam by phomoidrides and oxasetin against methicillin-resistant Staphylococcus aureus

Antimicrobial resistance (AMR) causes a global health threat and enormous damage for humans. Among them, Methicillin-resistant Staphylococcus aureus (MRSA) resistant to first-line therapeutic β-lactam drugs such as meropenem (MEPM) is problematic. Therefore, we focus on combination drug therapy and have been seeking new potentiators of MEPM to combat MRSA. In this paper, we report the isolation of phomoidrides A–D and its new analog, phomoidride H along with a polyketide compound, oxasetin from the culture broth of Neovaginatispora clematidis FKI-8547 strain as potentiators of MEPM against MRSA.

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来源期刊

Journal of Antibiotics 医学-免疫学

CiteScore

6.60

自引率

3.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Antibiotics seeks to promote research on antibiotics and related types of biologically active substances and publishes Articles, Review Articles, Brief Communication, Correspondence and other specially commissioned reports. The Journal of Antibiotics accepts papers on biochemical, chemical, microbiological and pharmacological studies. However, studies regarding human therapy do not fall under the journal’s scope. Contributions regarding recently discovered antibiotics and biologically active microbial products are particularly encouraged. Topics of particular interest within the journal''s scope include, but are not limited to, those listed below: Discovery of new antibiotics and related types of biologically active substances Production, isolation, characterization, structural elucidation, chemical synthesis and derivatization, biological activities, mechanisms of action, and structure-activity relationships of antibiotics and related types of biologically active substances Biosynthesis, bioconversion, taxonomy and genetic studies on producing microorganisms, as well as improvement of production of antibiotics and related types of biologically active substances Novel physical, chemical, biochemical, microbiological or pharmacological methods for detection, assay, determination, structural elucidation and evaluation of antibiotics and related types of biologically active substances Newly found properties, mechanisms of action and resistance-development of antibiotics and related types of biologically active substances.