绝经后妇女的乳腺造影参数与内源性激素的关系

IF 0.2 Q4 OBSTETRICS & GYNECOLOGY
Pascual García-Alfaro, Ignacio Rodríguez García, Jean L. Browne, Rafael Fábregas Xauradó
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引用次数: 0

摘要

材料和方法 对 363 名未使用绝经激素治疗的绝经后妇女进行横断面研究。研究收集了以下数据:年龄、绝经年龄、吸烟状况、体重指数、脂肪含量和体力活动。评估了血浆中促卵泡激素、雌二醇、睾酮、硫酸脱氢表雄酮(DHEAS)、∆ 4 雄烯二酮、皮质醇、胰岛素样生长因子-1(IGF-1)和 25-羟维生素 D 的水平。在选择潜在混杂变量时使用了有向无环图,并对混杂因素进行了线性回归调整,以研究内源性激素与乳腺X线摄影参数之间的关系。结果经混杂变量调整后的多变量线性回归分析表明,皮质醇(β = 0.20; 95% CI: 0.02; 0.37)和∆ 4 雄烯二酮(β = -1.90; 95% CI: - 3.30, - 0.39)与乳腺密度显著相关。IGF-1 (β = -0.01; 95% CI: - 0.20, - 0.01) 是唯一一种与腺体体积有显著相关性的激素。结论绝经后妇女较高的皮质醇水平和较低的∆ 4 雄烯二酮水平与较高的乳腺密度有关,而较高的 IGF-1 水平与较低的腺体体积有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mammographic parameters and endogenous hormones association in postmenopausal women

Objectives

To examine the association between endogenous hormones with mammographic breast density, glandular volume, and breast volume in postmenopausal women.

Material and methods

A cross-sectional study among 363 postmenopausal women not using menopausal hormonal treatment. The following data were collected: age, age at menopause, smoking status, body mass index, adiposity, and physical activity. Plasma levels of follicle-stimulating hormone, estradiol, testosterone, dehydroepiandrosterone sulfate (DHEAS), ∆ 4 androstenedione, cortisol, insulin-like growth factor-1 (IGF-1), and 25-hydroxyvitamin D were evaluated. Directed acyclic graph was used for the selection of potential confounding variables, and the linear regression was adjusted for confounders to study the association between endogenous hormones and mammographic parameters. Results are reported as β-coefficients (β) and 95% confidence interval (95% CI).

Results

Multivariable linear regression analysis adjusted for confounding variables showed that cortisol (β = 0.20; 95% CI: 0.02; 0.37), and ∆ 4 androstenedione (β = −1.90; 95% CI: − 3.30, − 0.39) were significantly associated with breast density. IGF-1 (β = −0.01; 95% CI: − 0.20, − 0.01) was the only hormone with significant association with glandular volume. No relationship was found between the studied hormones and breast volume.

Conclusions

Higher cortisol and lower ∆ 4 androstenedione levels are associated with higher breast density, and higher IGF-1 levels are associated with lower glandular volume in postmenopausal women.

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来源期刊
Revista de Senologia y Patologia Mamaria
Revista de Senologia y Patologia Mamaria Medicine-Obstetrics and Gynecology
CiteScore
0.30
自引率
0.00%
发文量
74
审稿时长
63 days
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