Pascual García-Alfaro, Ignacio Rodríguez García, Jean L. Browne, Rafael Fábregas Xauradó
{"title":"绝经后妇女的乳腺造影参数与内源性激素的关系","authors":"Pascual García-Alfaro, Ignacio Rodríguez García, Jean L. Browne, Rafael Fábregas Xauradó","doi":"10.1016/j.senol.2023.100562","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><p>To examine the association between endogenous hormones with mammographic breast density, glandular volume, and breast volume in postmenopausal women.</p></div><div><h3>Material and methods</h3><p><span><span><span>A cross-sectional study among 363 postmenopausal women not using menopausal hormonal treatment. The following data were collected: age, age at menopause, smoking status, </span>body mass index, adiposity, and physical activity. Plasma levels of follicle-stimulating hormone, estradiol, testosterone, </span>dehydroepiandrosterone sulfate (DHEAS), ∆</span> <span><span>4 androstenedione<span>, cortisol, insulin-like growth factor-1 (IGF-1), and 25-hydroxyvitamin D were evaluated. Directed acyclic graph was used for the selection of potential confounding variables, and the </span></span>linear regression was adjusted for confounders to study the association between endogenous hormones and mammographic parameters. Results are reported as β-coefficients (β) and 95% confidence interval (95% CI).</span></p></div><div><h3>Results</h3><p>Multivariable linear regression analysis adjusted for confounding variables showed that cortisol (β = 0.20; 95% CI: 0.02; 0.37), and ∆<!--> <!-->4 androstenedione (β = −1.90; 95% CI: −<!--> <!-->3.30, −<!--> <!-->0.39) were significantly associated with breast density. IGF-1 (β = −0.01; 95% CI: −<!--> <!-->0.20, −<!--> <!-->0.01) was the only hormone with significant association with glandular volume. No relationship was found between the studied hormones and breast volume.</p></div><div><h3>Conclusions</h3><p>Higher cortisol and lower ∆<!--> <!-->4 androstenedione levels are associated with higher breast density, and higher IGF-1 levels are associated with lower glandular volume in postmenopausal women.</p></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"37 1","pages":"Article 100562"},"PeriodicalIF":0.2000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Mammographic parameters and endogenous hormones association in postmenopausal women\",\"authors\":\"Pascual García-Alfaro, Ignacio Rodríguez García, Jean L. Browne, Rafael Fábregas Xauradó\",\"doi\":\"10.1016/j.senol.2023.100562\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objectives</h3><p>To examine the association between endogenous hormones with mammographic breast density, glandular volume, and breast volume in postmenopausal women.</p></div><div><h3>Material and methods</h3><p><span><span><span>A cross-sectional study among 363 postmenopausal women not using menopausal hormonal treatment. The following data were collected: age, age at menopause, smoking status, </span>body mass index, adiposity, and physical activity. Plasma levels of follicle-stimulating hormone, estradiol, testosterone, </span>dehydroepiandrosterone sulfate (DHEAS), ∆</span> <span><span>4 androstenedione<span>, cortisol, insulin-like growth factor-1 (IGF-1), and 25-hydroxyvitamin D were evaluated. Directed acyclic graph was used for the selection of potential confounding variables, and the </span></span>linear regression was adjusted for confounders to study the association between endogenous hormones and mammographic parameters. Results are reported as β-coefficients (β) and 95% confidence interval (95% CI).</span></p></div><div><h3>Results</h3><p>Multivariable linear regression analysis adjusted for confounding variables showed that cortisol (β = 0.20; 95% CI: 0.02; 0.37), and ∆<!--> <!-->4 androstenedione (β = −1.90; 95% CI: −<!--> <!-->3.30, −<!--> <!-->0.39) were significantly associated with breast density. IGF-1 (β = −0.01; 95% CI: −<!--> <!-->0.20, −<!--> <!-->0.01) was the only hormone with significant association with glandular volume. No relationship was found between the studied hormones and breast volume.</p></div><div><h3>Conclusions</h3><p>Higher cortisol and lower ∆<!--> <!-->4 androstenedione levels are associated with higher breast density, and higher IGF-1 levels are associated with lower glandular volume in postmenopausal women.</p></div>\",\"PeriodicalId\":38058,\"journal\":{\"name\":\"Revista de Senologia y Patologia Mamaria\",\"volume\":\"37 1\",\"pages\":\"Article 100562\"},\"PeriodicalIF\":0.2000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista de Senologia y Patologia Mamaria\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0214158223000944\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista de Senologia y Patologia Mamaria","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0214158223000944","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
Mammographic parameters and endogenous hormones association in postmenopausal women
Objectives
To examine the association between endogenous hormones with mammographic breast density, glandular volume, and breast volume in postmenopausal women.
Material and methods
A cross-sectional study among 363 postmenopausal women not using menopausal hormonal treatment. The following data were collected: age, age at menopause, smoking status, body mass index, adiposity, and physical activity. Plasma levels of follicle-stimulating hormone, estradiol, testosterone, dehydroepiandrosterone sulfate (DHEAS), ∆4 androstenedione, cortisol, insulin-like growth factor-1 (IGF-1), and 25-hydroxyvitamin D were evaluated. Directed acyclic graph was used for the selection of potential confounding variables, and the linear regression was adjusted for confounders to study the association between endogenous hormones and mammographic parameters. Results are reported as β-coefficients (β) and 95% confidence interval (95% CI).
Results
Multivariable linear regression analysis adjusted for confounding variables showed that cortisol (β = 0.20; 95% CI: 0.02; 0.37), and ∆ 4 androstenedione (β = −1.90; 95% CI: − 3.30, − 0.39) were significantly associated with breast density. IGF-1 (β = −0.01; 95% CI: − 0.20, − 0.01) was the only hormone with significant association with glandular volume. No relationship was found between the studied hormones and breast volume.
Conclusions
Higher cortisol and lower ∆ 4 androstenedione levels are associated with higher breast density, and higher IGF-1 levels are associated with lower glandular volume in postmenopausal women.