聚焦多发性硬化症视觉通路的跨突触退化

IF 3.1 Q1 OPHTHALMOLOGY

Eye and Brain Pub Date : 2023-12-29 eCollection Date: 2023-01-01 DOI:10.2147/EB.S389632

Angeliki G Filippatou, Peter A Calabresi, Shiv Saidha, Olwen C Murphy

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引用次数: 0

摘要

多发性硬化症（MS）神经退行性变的一种假定机制是跨突触变性（TSD），即神经元损伤导致突触相连的神经元变性。多发性硬化症通常涉及视觉系统，而视觉系统结构明确，因此是研究 TSD 的理想模型。TSD可能发生在前向方向（视神经病变导致后视通路变性，包括视神经放射和枕灰质）和/或后向方向（后视通路病变导致视网膜变性）。在本综述中，我们讨论了支持多发性硬化症患者视觉系统存在逆行和顺行 TSD 的证据。

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Spotlight on Trans-Synaptic Degeneration in the Visual Pathway in Multiple Sclerosis.

A putative mechanism of neurodegeneration in multiple sclerosis (MS) is trans-synaptic degeneration (TSD), whereby injury to a neuron leads to degeneration of synaptically connected neurons. The visual system is commonly involved in MS and provides an ideal model to study TSD given its well-defined structure. TSD may occur in an anterograde direction (optic neuropathy causing degeneration in the posterior visual pathway including the optic radiations and occipital gray matter) and/or retrograde direction (posterior visual pathway lesions causing retinal degeneration). In the current review, we discuss evidence supporting the presence of anterograde and retrograde TSD in the visual system in MS.

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来源期刊

Eye and Brain OPHTHALMOLOGY-

CiteScore

7.90

自引率

2.30%

发文量

审稿时长

16 weeks

期刊介绍： Eye and Brain is an international, peer-reviewed, open access journal focusing on basic research, clinical findings, and expert reviews in the field of visual science and neuro-ophthalmology. The journal’s unique focus is the link between two well-known visual centres, the eye and the brain, with an emphasis on the importance of such connections. All aspects of clinical and especially basic research on the visual system are addressed within the journal as well as significant future directions in vision research and therapeutic measures. This unique journal focuses on neurological aspects of vision – both physiological and pathological. The scope of the journal spans from the cornea to the associational visual cortex and all the visual centers in between. Topics range from basic biological mechanisms to therapeutic treatment, from simple organisms to humans, and utilizing techniques from molecular biology to behavior. The journal especially welcomes primary research articles or review papers that make the connection between the eye and the brain. Specific areas covered in the journal include: Physiology and pathophysiology of visual centers, Eye movement disorders and strabismus, Cellular, biochemical, and molecular features of the visual system, Structural and functional organization of the eye and of the visual cortex, Metabolic demands of the visual system, Diseases and disorders with neuro-ophthalmic manifestations, Clinical and experimental neuro-ophthalmology and visual system pathologies, Epidemiological studies.