对撒哈拉以南非洲地区用于治疗腹泻的药用植物的疗效和安全性进行范围审查。

IF 3.6 Q1 TROPICAL MEDICINE
Moitshepi T A Plaatjie, ThankGod E Onyiche, Tsepo Ramatla, Johannes J Bezuidenhout, Lesetja Legoabe, Nthatisi I Nyembe, Oriel Thekisoe
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引用次数: 0

摘要

背景:在撒哈拉以南非洲地区(SSA),严重的发病率和死亡率与腹泻有关,而腹泻通常是由微生物引起的。抗生素耐药性病原体的增加再次激发了人们对替代疗法的探索。本范围综述旨在对撒哈拉以南非洲地区有关药用植物止泻潜力的文献进行梳理:方法:在 Scopus、Web of Science、Science Direct 和 PubMed 上检索了 1990 年至 2022 年 4 月期间发表的有关撒南非洲各国用于治疗腹泻的药用植物的研究。选择文章的依据是是否有关于药用植物对腹泻疗效的体外和/或体内、人种植物学和横断面研究的数据。共有 67 篇文章(民族植物学(n = 40);体外(n = 11)、体内(n = 7)、横断面(n = 3)、体外和体内(n = 2)以及民族植物学和体外(n = 2))被考虑用于描述性分析,其中涉及研究特征、草药干预信息、植物化学、结果测量和毒性结果:结果:共发现了 587 种用于治疗腹泻的不同植物(来自 123 个科)。大多数研究都是针对豆科植物进行的。抗菌活性最强的植物是茵陈和石榴。使用色谱法从 Hydnora johannis 的乙酸乙酯提取物中分离出六种纯化合物,并使用光谱法确定其结构。大多数止泻植物来自南非(23.9%)、埃塞俄比亚(16.4%)和乌干达(9%)。这项研究强调了传统疗法在治疗撒哈拉以南非洲地区人类常见疾病(如腹泻)方面的价值:结论:研究发现了撒南非洲各地的基线知识差距。因此,建议今后的民族植物学研究记录迄今为止关注较少的撒南非洲其他国家所拥有的知识。此外,我们还建议今后的研究开展植物化学调查,特别是对广泛用于治疗腹泻疾病的药用植物进行调查,这可作为今后研究开发现代药物的基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A scoping review on efficacy and safety of medicinal plants used for the treatment of diarrhea in sub-Saharan Africa.

Background: In sub-Saharan Africa (SSA), significant morbidity and mortality have been linked to diarrhea, which is frequently caused by microorganisms. A rise in antimicrobial-resistant pathogens has reignited the search for alternative therapies. This scoping review aims to map the literature on medicinal plants in relation to their anti-diarrheal potential from SSA.

Methods: Studies published from 1990 until April 2022 on medicinal plants used for the treatment of diarrhea from each country in SSA were searched on Scopus, Web of Science, Science Direct and PubMed. The selection of articles was based on the availability of data on the in vitro and/or in vivo, ethnobotanical, and cross-sectional studies on the efficacy of medicinal plants against diarrhea. A total of 67 articles (ethnobotanical (n = 40); in vitro (n = 11), in vivo (n = 7), cross-sectional (n = 3), in vitro and in vivo (n = 2) and ethnobotanical and in vitro (n = 2), were considered for the descriptive analysis, which addressed study characteristics, herbal intervention information, phytochemistry, outcome measures, and toxicity findings.

Results: A total of 587 different plant species (from 123 families) used for diarrhea treatment were identified. Most studies were conducted on plants from the Fabaceae family. The plants with the strongest antimicrobial activity were Indigofera daleoides and Punica granatum. Chromatographic methods were used to isolate six pure compounds from ethyl acetate extract of Hydnora johannis, and spectroscopic methods were used to determine their structures. The majority of anti-diarrheal plants were from South Africa (23.9%), Ethiopia (16.4%), and Uganda (9%). This study highlights the value of traditional remedies in treating common human diseases such as diarrhea in SSA.

Conclusion: Baseline knowledge gaps were identified in various parts of SSA. It is therefore recommended that future ethnobotanical studies document the knowledge held by other countries in SSA that have so far received less attention. Additionally, we recommend that future studies conduct phytochemical investigations, particularly on the widely used medicinal plants for the treatment of diarrheal illnesses, which can serve as a foundation for future research into the development of contemporary drugs.

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来源期刊
Tropical Medicine and Health
Tropical Medicine and Health TROPICAL MEDICINE-
CiteScore
7.00
自引率
2.20%
发文量
90
审稿时长
11 weeks
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