可待因对食管运动失调患者食管蠕动的影响:使用高分辨率测压法进行的研究。

IF 3.3 3区 医学 Q2 CLINICAL NEUROLOGY
Wei-Yi Lei, Tso-Tsai Liu, Wei-Chuan Chang, Chih-Hsun Yi, Jui-Sheng Hung, Ming-Wun Wong, Shu-Wei Liang, Lin Lin, Chien-Lin Chen
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引用次数: 0

摘要

背景/目的本研究旨在评估急性服用可待因对食管运动功能不全(IEM)患者食管原发性和继发性蠕动的影响:研究共招募了 18 名 IEM 患者(8 名女性;平均年龄 37.8 岁,23-64 岁不等)。患者接受了高分辨率测压检查,包括 10 次单次湿润吞咽、多次快速吞咽和 10 次 20 毫升快速空气注射,以触发二次蠕动。所有参与者按随机顺序分别完成 2 个疗程,包括急性服用可待因(60 毫克)和安慰剂:结果:与安慰剂治疗后的这些参数相比,可待因明显增加了原发性蠕动的远端收缩积分(566 ± 81 mmHg∙s∙cm vs 247 ± 36 mmHg∙s∙cm, P = 0.001),缩短了远端潜伏期(5.7 ± 0.2 秒 vs 6.5 ± 0.1 秒,P < 0.001)。可待因治疗后的平均总断裂长度与安慰剂治疗后的长度相比明显减少(P = 0.003)。可待因能明显增加食管胃交界处的收缩积分(P = 0.028),但不会改变 4 秒钟的综合松弛压力(P = 0.794)。可待因能明显降低微弱收缩(P = 0.039)和失败收缩(P = 0.009)的频率,从而增加正常原发性蠕动的频率(P < 0.136)。多次快速吞咽抑制受损的比率和二次蠕动的参数没有发现明显差异:结论:在 IEM 患者中,急性服用可待因可增加收缩活力并减少食管原发性蠕动的远端潜伏期,但对继发性蠕动没有影响。未来的研究需要进一步阐明这些发现的临床意义,尤其是在胃食管反流病合并 IEM 的情况下。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of Codeine on Esophageal Peristalsis in Patients With Ineffective Esophageal Motility: Studies Using High-resolution Manometry.

Background/aims: This study aims to evaluate the effects of acute codeine administration on primary and secondary esophageal peristalsis in patients with ineffective esophageal motility (IEM).

Methods: Eighteen IEM patients (8 women; mean age 37.8 years, range 23-64 years) were enrolled in the study. The patients underwent high-resolution manometry exams, consisting of 10 single wet swallows, multiple rapid swallows, and ten 20 mL rapid air injections to trigger secondary peristalsis. All participants completed 2 separate sessions, including acute administration of codeine (60 mg) and placebo, in a randomized order.

Results: Codeine significantly increased the distal contractile integral (566 ± 81 mmHg∙s∙cm vs 247 ± 36 mmHg∙s∙cm, P = 0.001) and shortened distal latency (5.7 ± 0.2 seconds vs 6.5 ± 0.1 seconds, P < 0.001) for primary peristalsis compared with these parameters after placebo treatment. The mean total break length decreased significantly after codeine treatment compared with the length after placebo (P = 0.003). Codeine significantly increased esophagogastric junction-contractile integral (P = 0.028) but did not change the 4-second integrated relaxation pressure (P = 0.794). Codeine significantly decreased the frequency of weak (P = 0.039) and failed contractions (P = 0.009), resulting in increased frequency of normal primary peristalsis (P < 0.136). No significant differences in the ratio of impaired multiple rapid swallows inhibition and parameters of secondary peristalsis were detected.

Conclusions: In IEM patients, acute administration of codeine increases contraction vigor and reduces distal latency of primary esophageal peristalsis, but has no effect on secondary peristalsis. Future studies are required to further elucidate clinical relevance of these findings, especially in the setting of gastroesophageal reflux disease with IEM.

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来源期刊
Journal of Neurogastroenterology and Motility
Journal of Neurogastroenterology and Motility GASTROENTEROLOGY & HEPATOLOGY-CLINICAL NEUROLOGY
CiteScore
6.30
自引率
8.80%
发文量
96
期刊介绍: Journal of Neurogastroenterology and Motility (J Neurogastroenterol Motil) is a joint official journal of the Korean Society of Neurogastroenterology and Motility, the Thai Neurogastroenterology and Motility Society, the Japanese Society of Neurogastroenterology and Motility, the Indian Motility and Functional Disease Association, the Chinese Society of Gastrointestinal Motility, the South East Asia Gastro-Neuro Motility Association, the Taiwan Neurogastroenterology and Motility Society and the Asian Neurogastroenterology and Motility Association, launched in January 2010 after the title change from the Korean Journal of Neurogastroenterology and Motility, published from 1994 to 2009.
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