为获得功能而进行抗体糖工程设计的最新进展

IF 6.9 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current Opinion in Chemical Biology Pub Date : 2024-01-03 DOI:10.1016/j.cbpa.2023.102420

Zhi Liu , Xiangman Zou , Feng Tang , Wei Huang

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引用次数: 0

摘要

聚糖在抗体功能中发挥着重要作用，抗体糖工程长期以来一直是一个重要的研究领域。在此，我们总结了抗体糖工程的重要策略，包括哺乳动物细胞表达系统中的表达抗体糖工程、化学酶抗体糖工程和基于酵母表达系统的抗体工程，以及糖工程在抗体-药物共轭物中的应用。这些抗体糖工程方面的进展将为我们提供一个全面的认识，并启发我们开发更先进的技术来实现糖工程抗体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Recent advances in antibody glycoengineering for the gain of functions

Glycans play important roles in antibody functions, and antibody glycoengineering has long been an important research field. Here, we summarize the significant strategies of antibody glycoengineering, including expressed antibody glycoengineering in mammalian cell expression systems, chemo-enzymatic antibody glycoengineering, and yeast expression system-based antibody engineering, as well as the applications of glycoengineering in antibody-drug conjugates. These advances in antibody glycoengineering will provide a comprehensive understanding and inspire us to develop more advanced techniques to achieve glycoengineered antibodies.

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来源期刊

Current Opinion in Chemical Biology 生物-生化与分子生物学

CiteScore

13.30

自引率

1.30%

发文量

113

审稿时长

74 days

期刊介绍： COCHBI (Current Opinion in Chemical Biology) is a systematic review journal designed to offer specialists a unique and educational platform. Its goal is to help professionals stay informed about the growing volume of information in the field of Chemical Biology through systematic reviews.