DIRAS3 在 KRAS 驱动的胰腺癌和卵巢癌中诱导自噬并提高对抗自噬疗法的敏感性

IF 14.6 1区生物学 Q1 CELL BIOLOGY

Autophagy Pub Date : 2024-01-03 DOI:10.1080/15548627.2023.2299516

Gamze Bildik, Joshua P. Gray, Weiqun Mao, Hailing Yang, Rumeysa Ozyurt, Vivian R. Orellana, Olivier De Wever, Mark S. Carey, Robert C. Bast, Zhen Lu

引用次数: 0

摘要

胰腺导管腺癌（PDAC）和低级别卵巢癌（LGSOC）的特点是普遍存在KRAS癌基因突变。DIRAS3是第一种内源性非RAS蛋白，它能抑制KRAS基因突变。

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DIRAS3 induces autophagy and enhances sensitivity to anti-autophagic therapy in KRAS-driven pancreatic and ovarian carcinomas

Pancreatic ductal adenocarcinoma (PDAC) and low-grade ovarian cancer (LGSOC) are characterized by the prevalence of KRAS oncogene mutations. DIRAS3 is the first endogenous non-RAS protein that hete...

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来源期刊

Autophagy 生物-细胞生物学

CiteScore

21.30

自引率

2.30%

发文量

277

审稿时长

1 months

期刊介绍： Autophagy is a peer-reviewed journal that publishes research on autophagic processes, including the lysosome/vacuole dependent degradation of intracellular material. It aims to be the premier journal in the field and covers various connections between autophagy and human health and disease, such as cancer, neurodegeneration, aging, diabetes, myopathies, and heart disease. Autophagy is interested in all experimental systems, from yeast to human. Suggestions for specialized topics are welcome. The journal accepts the following types of articles: Original research, Reviews, Technical papers, Brief Reports, Addenda, Letters to the Editor, Commentaries and Views, and Articles on science and art. Autophagy is abstracted/indexed in Adis International Ltd (Reactions Weekly), EBSCOhost (Biological Abstracts), Elsevier BV (EMBASE and Scopus), PubMed, Biological Abstracts, Science Citation Index Expanded, Web of Science, and MEDLINE.