用于功能强大的生物传感的 Aptamer-磁性纳米粒子复合物:全面回顾。

IF 4.2 2区 化学 Q1 CHEMISTRY, ANALYTICAL
Farag M A Altalbawy, Eyhab Ali, Mohammed N Fenjan, Yasser Fakri Mustafa, Sofiene Mansouri, Bokov D O, Sharipova Gulnikhol Idiyevna, Neeti Misra, Ahmed Hussien Alawadi, Ali Alsalamy
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引用次数: 0

摘要

对疾病进行选择性和敏感性诊断,是疾病治疗早期阶段的一项重要工作。详细而言,尽管有几种探针已广泛应用于临床,但磁性纳米材料-适配体作为新一代探针正变得越来越有吸引力。磁性纳米材料的存在带来了生物医学的定量、纯化和定量分析,尤其是在复杂样本中。具体来说,磁性纳米材料的超顺磁性能和大量功能化基团被认为是分别提供分离能力和固定基质的两个主要因素。此外,适配体的选择性和稳定性也是一种极具潜力的识别元素。重要的是,将适配体和磁性纳米材料的优势结合起来,可以提高生物医学分析中生物传感器的性能,推出高效、紧凑的探针,这种探针需要的病人样本少,诊断速度快,应用方便,而且在生物分子定量方面具有高重复性。本综述的主要目的是总结在制造基于磁性纳米材料的新型灵敏传感器时所采用的其他类型纳米材料的效果,并仔细探讨这些探针在生物试剂定量中的各种应用。此外,还讨论了这些多功能、高潜力探针在检测癌细胞和生物标记物、蛋白质、药物、细菌和核苷方面的应用。此外,还将讨论磁性纳米材料-触媒在生物医学分析领域的研究空白和限制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Aptamer-Magnetic Nanoparticle Complexes for Powerful Biosensing: A Comprehensive Review.

The selective and sensitive diagnosis of diseases is a significant matter in the early stages of the cure of illnesses. To elaborate, although several types of probes have been broadly applied in clinics, magnetic nanomaterials-aptamers, as new-generation probes, are becoming more and more attractive. The presence of magnetic nanomaterials brings about quantification, purification, and quantitative analysis of biomedical, especially in complex samples. Elaborately, the superparamagnetic properties and numerous functionalized groups of magnetic nanomaterials are considered two main matters for providing separation ability and immobilization substrate, respectively. In addition, the selectivity and stability of aptamer can present a high potential recognition element. Importantly, the integration of aptamer and magnetic nanomaterials benefits can boost the performance of biosensors for biomedical analysis by introducing efficient and compact probes that need low patient samples and fast diagnosis, user-friendly application, and high repeatability in the quantification of biomolecules. The primary aim of this review is to suggest a summary of the effect of the employed other types of nanomaterials in the fabrication of novel aptasensors-based magnetic nanomaterials and to carefully explore various applications of these probes in the quantification of bioagents. Furthermore, the application of these versatile and high-potential probes in terms of the detection of cancer cells and biomarkers, proteins, drugs, bacteria, and nucleoside were discussed. Besides, research gaps and restrictions in the field of biomedical analysis by magnetic nanomaterials-aptamers will be discussed.

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来源期刊
CiteScore
12.00
自引率
4.00%
发文量
137
审稿时长
6 months
期刊介绍: Critical Reviews in Analytical Chemistry continues to be a dependable resource for both the expert and the student by providing in-depth, scholarly, insightful reviews of important topics within the discipline of analytical chemistry and related measurement sciences. The journal exclusively publishes review articles that illuminate the underlying science, that evaluate the field''s status by putting recent developments into proper perspective and context, and that speculate on possible future developments. A limited number of articles are of a "tutorial" format written by experts for scientists seeking introduction or clarification in a new area. This journal serves as a forum for linking various underlying components in broad and interdisciplinary means, while maintaining balance between applied and fundamental research. Topics we are interested in receiving reviews on are the following: · chemical analysis; · instrumentation; · chemometrics; · analytical biochemistry; · medicinal analysis; · forensics; · environmental sciences; · applied physics; · and material science.
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