住院对结缔组织病相关间质性肺病患者死亡率的影响:病历回顾研究

IF 2 4区 医学 Q3 RHEUMATOLOGY
Anna Korogodina, Navneet Kaur, Xianhong Xie, Adhya Mehta, Krystal L. Cleven, Bibi Ayesha, Anand Kumthekar
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引用次数: 0

摘要

间质性肺病(ILD)仍然是结缔组织病(CTD)患者发病和死亡的最重要原因之一。本研究评估了不同民族和种族的 CTD-ILD 患者住院对死亡率的影响。我们在纽约州布朗克斯的蒙特菲奥里医疗中心开展了一项病历回顾研究。我们共纳入了 96 名患者,并收集了有关人口统计学特征、住院原因、住院时间、免疫抑制剂使用情况和死亡率的数据。我们将患者分为两组:住院患者和非住院患者。住院患者又分为心肺入院和非心肺入院。连续变量采用双样本检验或 Wilcoxon 秩和检验,分类变量采用卡方检验或费雪精确检验。我们确定了 213 名 CTD-ILD 患者。其中,96 名患者符合研究的纳入标准。大多数患者为女性(79%),自我认同为西班牙裔(54%)和黑人(40%)。最常见的 CTD 是类风湿性关节炎(RA)(29%)、炎症性肌炎(22%)和系统性硬化症(15%)。大多数患者(76%)至少需要住院治疗一次。在非住院组中,没有观察到死亡病例,但我们注意到住院组的死亡风险显著增加(p = 0.02)。我们还发现,住院时间延长(> 7 天)、年龄增大和男性与死亡率增加有关。在我们的 CTD-ILD 患者队列中,住院时间延长(> 7 天)、因心肺原因住院、年龄较大和男性与死亡率风险增加有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The impact of hospitalization on mortality in patients with connective tissue disease-associated interstitial lung disease: a medical records review study
Interstitial lung disease (ILD) remains one of the most important causes of morbidity and mortality in patients with Connective Tissue Diseases (CTD). This study evaluated the impact of hospitalization on mortality in an ethnically and racially diverse cohort of CTD-ILD patients. We conducted a medical records review study at Montefiore Medical Center, Bronx, NY. We included 96 patients and collected data on demographic characteristics, reasons for hospitalization, length of stay, immunosuppressant therapy use, and mortality. We stratified our patients into two cohorts: hospitalized and non-hospitalized. The hospitalized cohort was further subdivided into cardiopulmonary and non-cardiopulmonary admissions. Two-sample tests or Wilcoxon’s rank sum tests for continuous variables and Chi-square or Fisher’s exact tests for categorical variables were used for analyses as deemed appropriate. We identified 213 patients with CTD-ILD. Out of them, 96 patients met the study’s inclusion criteria. The majority of patients were females (79%), and self-identified as Hispanic (54%) and Black (40%). The most common CTDs were rheumatoid arthritis (RA) (29%), inflammatory myositis (22%), and systemic sclerosis (15%). The majority (76%) of patients required at least one hospitalization. In the non-hospitalized group, no deaths were observed, however we noted significant increase of mortality risk in hospitalized group (p = 0.02). We also observed that prolonged hospital stay (> 7 days) as well as older age and male sex were associated with increased mortality. Prolonged (> 7 days) hospital stay and hospitalization for cardiopulmonary causes, as well as older age and male sex were associated with an increased mortality risk in our cohort of CTD-ILD patients.
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来源期刊
Advances in Rheumatology
Advances in Rheumatology Medicine-Rheumatology
CiteScore
4.00
自引率
4.30%
发文量
41
审稿时长
53 weeks
期刊介绍: Formerly named Revista Brasileira de Reumatologia, the journal is celebrating its 60th year of publication. Advances in Rheumatology is an international, open access journal publishing pre-clinical, translational and clinical studies on all aspects of paediatric and adult rheumatic diseases, including degenerative, inflammatory and autoimmune conditions. The journal is the official publication of the Brazilian Society of Rheumatology and welcomes original research (including systematic reviews and meta-analyses), literature reviews, guidelines and letters arising from published material.
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