癌症干细胞:克服抗药性和复发的靶点。

IF 5.6 2区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Shuo Zhang, Rui Yang, Yujie Ouyang, Yang Shen, Lanlin Hu, Chuan Xu
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引用次数: 0

摘要

癌症干细胞(CSCs)是癌症中的一小部分细胞,被认为会引发肿瘤转化,促进转移、复发和抗药性。越来越多的证据显示,各种类型的癌症中都存在癌症干细胞,并表明癌症干细胞会分化成不同的系细胞,从而促进肿瘤的发展。如果我们能全面了解 CSCs 的生物学特征和耐药性机制,就有可能克服癌症治疗的局限性。本综述概述了 CSCs 的特性、生物标志物和耐药机制。重点介绍了有关代谢特征的最新发现,尤其是 CSCs 中的脂肪酸代谢和铁变态反应,以及前景看好的靶向策略。靶向 CSCs 是征服癌症、防止癌症治疗中的抗药性和复发的潜在治疗方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cancer stem cells: a target for overcoming therapeutic resistance and relapse.

Cancer stem cells (CSCs) are a small subset of cells in cancers that are thought to initiate tumorous transformation and promote metastasis, recurrence, and resistance to treatment. Growing evidence has revealed the existence of CSCs in various types of cancers and suggested that CSCs differentiate into diverse lineage cells that contribute to tumor progression. We may be able to overcome the limitations of cancer treatment with a comprehensive understanding of the biological features and mechanisms underlying therapeutic resistance in CSCs. This review provides an overview of the properties, biomarkers, and mechanisms of resistance shown by CSCs. Recent findings on metabolic features, especially fatty acid metabolism and ferroptosis in CSCs, are highlighted, along with promising targeting strategies. Targeting CSCs is a potential treatment plan to conquer cancer and prevent resistance and relapse in cancer treatment.

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来源期刊
Cancer Biology & Medicine
Cancer Biology & Medicine Medicine-Oncology
CiteScore
9.80
自引率
3.60%
发文量
1143
审稿时长
12 weeks
期刊介绍: Cancer Biology & Medicine (ISSN 2095-3941) is a peer-reviewed open-access journal of Chinese Anti-cancer Association (CACA), which is the leading professional society of oncology in China. The journal quarterly provides innovative and significant information on biological basis of cancer, cancer microenvironment, translational cancer research, and all aspects of clinical cancer research. The journal also publishes significant perspectives on indigenous cancer types in China.
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