Wanyu Huang, Leah H Schinasi, Chén C Kenyon, Amy H Auchincloss, Kari Moore, Steven Melly, Lucy F Robinson, Christopher B Forrest, Anneclaire J De Roos
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引用次数: 0
摘要
超过 80% 的儿童哮喘恶化与呼吸道病毒感染有关。呼吸道病毒感染会促进促炎介质的释放，尤其是对接触花粉/霉菌的过敏人群。我们采用时间序列研究设计，调查了呼吸道病毒感染对空气过敏原/PM2.5 与哮喘恶化率之间关系的可能影响。我们从费城儿童医院 2011 年至 2016 年的电子健康记录中获取了哮喘患儿（28,540/24,444 [温暖/寒冷季节]）中因哮喘加重而就诊的门诊患者、急诊科（ED）患者和住院患者的人数以及病毒感染人数。晚季青草花粉的比率比（RRs，第90百分位数 vs. 0）分别为1.00（0.85-1.17）、1.04（0.95-1.15）和1.12（0.96-1.32），呼吸道合胞病毒（RSV）计数在每个三分位数内的比率比（RRs，第90百分位数 vs. 0）分别为1.00（0.85-1.17）、1.04（0.95-1.15）和1.12（0.96-1.32）。然而，在杂草花粉/霉菌或 PM2.5 中没有观察到类似的趋势。总之，我们的研究几乎没有提供证据支持呼吸道病毒感染对效果的影响。
Do respiratory virus infections modify associations of asthma exacerbation with aeroallergens or fine particulate matter? A time series study in Philadelphia PA.
Respiratory virus infections are related to over 80% of childhood asthma exacerbations. They enhance pro-inflammatory mediator release, especially for sensitized individuals exposed to pollens/molds. Using a time-series study design, we investigated possible effect modification by respiratory virus infections of the associations between aeroallergens/PM2.5 and asthma exacerbation rates. Outpatient, emergency department (ED), and inpatient visits for asthma exacerbation among children with asthma (28,540/24,444 [warm/cold season]), as well as viral infection counts were obtained from electronic health records of the Children's Hospital of Philadelphia from 2011 to 2016. Rate ratios (RRs, 90th percentile vs. 0) for late-season grass pollen were 1.00 (0.85-1.17), 1.04 (0.95-1.15), and 1.12 (0.96-1.32), respectively, for respiratory syncytial virus (RSV) counts within each tertile. However, similar trends were not observed for weed pollens/molds or PM2.5. Overall, our study provides little evidence supporting effect modification by respiratory viral infections.
期刊介绍：
International Journal of Environmental Health Research ( IJEHR ) is devoted to the rapid publication of research in environmental health, acting as a link between the diverse research communities and practitioners in environmental health. Published articles encompass original research papers, technical notes and review articles. IJEHR publishes articles on all aspects of the interaction between the environment and human health. This interaction can broadly be divided into three areas: the natural environment and health – health implications and monitoring of air, water and soil pollutants and pollution and health improvements and air, water and soil quality standards; the built environment and health – occupational health and safety, exposure limits, monitoring and control of pollutants in the workplace, and standards of health; and communicable diseases – disease spread, control and prevention, food hygiene and control, and health aspects of rodents and insects. IJEHR is published in association with the International Federation of Environmental Health and includes news from the Federation of international meetings, courses and environmental health issues.
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