重型β-地中海贫血患者的促氧化剂/抗氧化剂平衡与血液参数的关系:一项横断面研究。

IF 2.3 Q2 HEMATOLOGY
Maryam Parvizi, Maryam Deldadeh Moghaddam, Shiva Nazari, Hami Ashraf, Maryam Kazemi Aghdam
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引用次数: 0

摘要

背景:重型地中海贫血(BTM)患者因铁蓄积而产生的氧化应激会导致组织损伤和破坏等并发症。本研究旨在评估 BTM 患者血清原氧化剂/抗氧化剂平衡(PAB)与血液参数之间的关联:这项横断面研究包括 92 名 BTM 患者。本研究采用酶联免疫吸附测定法(ELISA)测量原氧化剂/抗氧化剂平衡。研究还记录了血清铁蛋白、血尿素氮 (BUN)、肌酐 (Cr)、丙氨酸氨基转移酶 (ALT)、天冬氨酸氨基转移酶 (AST)、促甲状腺激素 (TSH)、总胆固醇 (TC)、甘油三酯 (TG)、全血细胞计数 (CBC) 和输血史。结果显示,高血清铁蛋白与低血清铁蛋白之间的关系非常密切:结果显示,高血清铁蛋白与血清 PAB 直接相关[几率比(OR),12.80;95% 置信区间(CI),2.98-54.91;T3 与 T1]。此外,高 TC(OR,4.97;95% CI,1.42-17.32;T3 vs. T1)、高 ALT(OR,4.95;95% CI,1.33-18.46;T3 vs. T1)和高 TSH(OR,3.78;95% CI,1.10-13.02;T3 vs. T1)也与 PAB 直接相关:本研究结果表明,血清 PAB 水平与铁蛋白、谷丙转氨酶、总胆固醇和促甲状腺激素水平直接相关。这表明,BTM 患者血液参数的改善,尤其是铁蛋白和促甲状腺激素水平的改善,是通过改善氧化应激而实现的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The association of pro-oxidant/antioxidant balance and blood parameters in patients with beta-thalassemia major: a cross-sectional study.

Background: Oxidative stress due to iron accumulation in patients with beta-thalassemia major (BTM) causes complications such as tissue damage and destruction. This study aimed to assess the association between the serum prooxidant/antioxidant balance (PAB) and blood parameters in patients with BTM.

Methods: This cross-sectional study included 92 patients with BTM. In this study, PAB was measured using an enzyme-linked immunosorbent assay (ELISA). Serum ferritin, blood urea nitrogen (BUN), creatinine (Cr), alanine aminotransferase (ALT), aspartate aminotransferase (AST), thyroid-stimulating hormone (TSH), total cholesterol (TC), triglyceride (TG), complete blood cell count (CBC), and history of blood transfusion were recorded. The association of the blood parameters was assessed across the tertiles (T) of serum PAB (highest T vs. lowest T).

Results: The results showed that high serum ferritin was directly associated with serum PAB [odds ratio (OR), 12.80; 95% confidence interval (CI), 2.98‒54.91; T3 vs. T1]. Also, direct associations were found for high TC (OR, 4.97; 95% CI, 1.42‒17.32; T3 vs. T1), high ALT (OR, 4.95; 95% CI, 1.33‒18.46; T3 vs. T1) and high TSH (OR, 3.78; 95% CI, 1.10‒13.02; T3 vs. T1).

Conclusion: The findings of the present study showed that serum PAB levels were directly associated with ferritin, ALT, TC, and TSH levels. This indicates that improvements in blood parameters, especially ferritin and TSH levels, occur by ameliorating oxidative stress in patients with BTM.

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来源期刊
Blood Research
Blood Research HEMATOLOGY-
CiteScore
3.70
自引率
0.00%
发文量
64
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