植物次生代谢物及其在 "超级细菌时代 "可能发挥的作用。

Q3 Biochemistry, Genetics and Molecular Biology
V M Nesterovich, D A Belykh, N V Gorokhovets, L K Kurbatov, A A Zamyatnin, L N Ikryannikova
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引用次数: 0

摘要

细菌感染是全球发病率和死亡率居高不下的一个严重原因。过去几十年来,细菌病原体的耐药性一直在稳步上升,而新的有效抗菌药物的开发率却始终很低。植物王国有时被称为寻找新抗菌疗法的无底洞。这是因为植物易于获取,加工成本低廉,而且植物提取物和成分通常具有很高的生物活性,副作用小。从植物原料中获得的化合物种类繁多,有多种化学结构可供选择,可与细菌细胞内的各种靶点相互作用,而现代生物技术工具的快速发展则为有针对性地生产具有所需特性的生物活性成分开辟了道路。本综述旨在回答这样一个问题:在 "后抗生素时代",植物源抗菌剂是否有机会在抗击传染病的斗争中发挥灵丹妙药的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Secondary metabolites of plants and their possible role in the "age of superbugs".

Bacterial infections are a serious cause of high morbidity and mortality worldwide. Over the past decades, the drug resistance of bacterial pathogens has been steadily increasing, while the rate of development of new effective antibacterial drugs remains consistently low. The plant kingdom is sometimes called a bottomless well for the search for new antimicrobial therapies. This is due to the fact that plants are easily accessible and cheap to process, while extracts and components of plant origin often demonstrate a high level of biological activity with minor side effects. The variety of compounds obtained from plant raw materials can provide a wide choice of various chemical structures for interaction with various targets inside bacterial cells, while the rapid development of modern biotechnological tools opens the way to the targeted production of bioactive components with desired properties. The objective of this review is to answer the question, whether antimicrobials of plant origin have a chance to play the role of a panacea in the fight against infectious diseases in the "post-antibiotic era".

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来源期刊
Biomeditsinskaya khimiya
Biomeditsinskaya khimiya Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
1.30
自引率
0.00%
发文量
49
期刊介绍: The aim of the Russian-language journal "Biomeditsinskaya Khimiya" (Biomedical Chemistry) is to introduce the latest results obtained by scientists from Russia and other Republics of the Former Soviet Union. The Journal will cover all major areas of Biomedical chemistry, including neurochemistry, clinical chemistry, molecular biology of pathological processes, gene therapy, development of new drugs and their biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine etc. The Journal also publish review articles. All issues of journal usually contain invited reviews. Papers written in Russian contain abstract (in English).
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