Jing Yang, Yuping He, Meng Zhang, Chenglin Liang, Tongtong Li, Tianjiao Ji, Mali Zu, Xu Ma, Zhenzhong Zhang, Chun Liang, Qixu Zhang, Youbai Chen, Lin Hou
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Front Cover: Programmed initiation and enhancement of cGAS/STING pathway for tumour immunotherapy via tailor-designed ZnFe2O4-based nanosystem (EXP2 6/2023)
Hou et al. constructed tumor intracellular microenvironment responsive ZnFe2O4 nanoparticles loading low-dose paclitaxel (PTX) which encapsulated with cancer cell membrane (CCM)(ZnFe2O4-PTX@CCM). ZnFe2O4-PTX@CCM could release Fe3+, Zn2+ and PTX in the tumor cytoplasm by responding to the high level of GSH, and thus stimulate anti-tumor immunity by enhancing the cGAS/STING pathway.
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