封面内页：表面工程沙门氏菌与pH响应性聚舍洛托宁和自激活DNA酶，用于更好的肿瘤微生物治疗（EXP2 6/2023）

Exploration (Beijing, China) Pub Date : 2023-12-22 DOI:10.1002/EXP.20230602

Lina Guo, Hao Chen, Jinsong Ding, Pengfei Rong, Ming Sun, Wenhu Zhou

{"title":"封面内页：表面工程沙门氏菌与pH响应性聚舍洛托宁和自激活DNA酶，用于更好的肿瘤微生物治疗（EXP2 6/2023）","authors":"Lina Guo, Hao Chen, Jinsong Ding, Pengfei Rong, Ming Sun, Wenhu Zhou","doi":"10.1002/EXP.20230602","DOIUrl":null,"url":null,"abstract":"<p>Zhou et al. have developed pH-responsive polyserotonin-modified Salmonella carrying a self-activated DNAzyme. This novel platform minimizes immune clearance, selectively disassembling in the tumor's acidic microenvironment to reactivate <i>Salmonella</i> and release DNAzyme. This “Trojan horse” strategy improves therapeutic outcomes.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"3 6","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230602","citationCount":"0","resultStr":"{\"title\":\"Inside Front Cover: Surface engineering Salmonella with pH-responsive polyserotonin and self-activated DNAzyme for better microbial therapy of tumor (EXP2 6/2023)\",\"authors\":\"Lina Guo, Hao Chen, Jinsong Ding, Pengfei Rong, Ming Sun, Wenhu Zhou\",\"doi\":\"10.1002/EXP.20230602\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Zhou et al. have developed pH-responsive polyserotonin-modified Salmonella carrying a self-activated DNAzyme. This novel platform minimizes immune clearance, selectively disassembling in the tumor's acidic microenvironment to reactivate <i>Salmonella</i> and release DNAzyme. This “Trojan horse” strategy improves therapeutic outcomes.\\n\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure></p>\",\"PeriodicalId\":72997,\"journal\":{\"name\":\"Exploration (Beijing, China)\",\"volume\":\"3 6\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-12-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230602\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Exploration (Beijing, China)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/EXP.20230602\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Exploration (Beijing, China)","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/EXP.20230602","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

Zhou等人开发了携带自激活DNA酶的pH响应型多羟色胺修饰沙门氏菌。这种新型平台能最大限度地减少免疫清除，在肿瘤的酸性微环境中选择性地分解沙门氏菌，重新激活沙门氏菌并释放DNA酶。这种 "特洛伊木马 "策略提高了治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Inside Front Cover: Surface engineering Salmonella with pH-responsive polyserotonin and self-activated DNAzyme for better microbial therapy of tumor (EXP2 6/2023)

查看原文本刊更多论文

Inside Front Cover: Surface engineering Salmonella with pH-responsive polyserotonin and self-activated DNAzyme for better microbial therapy of tumor (EXP2 6/2023)

Zhou et al. have developed pH-responsive polyserotonin-modified Salmonella carrying a self-activated DNAzyme. This novel platform minimizes immune clearance, selectively disassembling in the tumor's acidic microenvironment to reactivate Salmonella and release DNAzyme. This “Trojan horse” strategy improves therapeutic outcomes.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Exploration (Beijing, China)

CiteScore

17.20

自引率

0.00%

发文量