结膜、输卵管和子宫内膜皮下自体移植模型中沙眼衣原体眼生殖器感染的研究。

D L Patton, C C Kuo, R M Brenner
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引用次数: 0

摘要

本文描述了用于研究猴子沙眼衣原体感染的输卵管、子宫内膜和结膜自体移植物的皮下袋模型。输卵管移植的部分包括肠膜、壶腹和峡部。该模型是原始模型的扩展,由输卵管膜或结膜自体移植物组成。输卵管壶腹部分的移植使我们能够增加囊或测试部位的数量。输卵管和结膜自体移植物可以在一次手术中建立。此外,自体子宫内膜移植也可能引起子宫内膜炎。自体移植物易受沙眼衣原体感染。初步的再挑战实验表明,皮下移植物感染可诱导免疫,表明该模型可用于免疫和疫苗研究。同时移植不同部位的输卵管、子宫内膜和结膜应该扩大皮下模型在其他混合感染或感染免疫反应研究中的有用性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Chlamydia trachomatis oculogenital infection in the subcutaneous autotransplant model of conjunctiva, salpinx and endometrium.

The subcutaneous pocket model of salpingeal, endometrial, and conjunctival autografts for studying Chlamydia trachomatis infection in monkeys is described. Portions of the salpinx that were transplanted included fimbria, ampulla, and isthmus. The model is an extension of the original model which consists of either salpingeal fimbria or conjunctive autografts. Transplantation of the ampulla portion of the Fallopian tube enabled us to increase the number of pockets or test sites. Salpingeal and conjunctival autografts could be established during a single surgery. In addition, it is possible to autotransplant endometrium and provoke endometritis. The autografts were shown to be susceptible to C. trachomatis infection. Preliminary rechallenge experiments showed infection of the subcutaneous transplants may induce immunity, indicating the model may be used for immunity and vaccine studies. Simultaneous transplantation of different parts of the oviduct, endometrium, and conjunctive should expand the usefulness of the subcutaneous model in other studies on mixed infections or immune responses to infection.

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