Zainab Assy, William Murray Thomson, Henk S Brand, Seunghee Cha, Merve M Susam, Gary A Weisman, Arjan Vissink, Floris J Bikker, Derk Hendrik Jan Jager
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引用次数: 0
摘要
目的：迄今为止，口干症量表（Xerostomia Inventory，XI）的临床相关改善程度尚未确定。因此，我们的目的是确定 XI 对改善 SjD 患者口干症状的最小重要差异 (MID)：研究招募了 34 名接受主要唾液腺内窥镜检查的 SjD 患者和 15 名未接受干预的对照组 SjD 患者。在多个时间点对 XI 评分进行评估。根据有改善组和无改善组之间 XI 评分的平均差异确定 MID：结果：对照组的 XI 评分没有明显变化。巩膜内窥镜检查组的 XI 评分在一周后发生了四分的临床相关变化。如果持续时间较长（≥16 周），XI 评分至少要降低 7 个量表点才能表明有临床意义的改善：结论：在评估短期疗效时，SjD 患者的 XI 评分至少要有 4 分的变化才能表明临床相关的改善。对于长期疗效，临床相关的改善需要达到 7 分的 MID。确定 XI 的 MID 值有助于今后评估口腔异味变化的研究。
The minimally important difference for the Xerostomia Inventory among Sjögren's disease patients.
Objective: Until now, the clinically relevant improvement for the Xerostomia Inventory (XI) has not been defined. Therefore, our aim was to determine the Minimally Important Difference (MID) of the XI for improvement in dry-mouth symptoms in SjD patients.
Method: The study recruited 34 SjD patients who underwent sialendoscopy of major salivary glands and 15 SjD patients in a nonintervention control group. XI scores were assessed at several time points. The MID was determined from the mean difference in XI scores between the groups with and without improvement.
Results: In the control group, no significant XI score changes were seen. In the sialendoscopy group, a clinically relevant XI score change of four scale points was identified after 1 week. For a prolonged duration (≥16 weeks), a minimum reduction of seven scale points in the XI score was required to indicate clinically relevant improvement.
Conclusion: In SjD patients, a minimum change of four points in the XI score indicates a clinically relevant improvement for evaluating short-term effects. For prolonged effects, a clinically relevant improvement requires a MID of seven points. The determination of the MID in XI could assist in future studies that evaluate changes in xerostomia.
期刊介绍：
Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.
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