DNA 双链断裂反应中的相位分离。

Nucleus (Austin, Tex.) Pub Date : 2024-12-01 Epub Date: 2023-12-25 DOI:10.1080/19491034.2023.2296243
Huan-Lei Liu, Hao Nan, Wan-Wen Zhao, Xiang-Bo Wan, Xin-Juan Fan
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引用次数: 0

摘要

DNA双链断裂(DSB)是最危险的DNA损伤类型,可能导致细胞死亡或致癌突变。同源重组(HR)和非同源末端连接(NHEJ)是两种典型的DSB修复机制。最近,许多研究发现,液-液相分离(LLPS)在DSB修复和反应中发挥着关键作用。通过LLPS,关键的生物大分子被高浓度地快速招募到受损位点,确保DNA修复快速高效地进行,从而促进DSB修复因子激活下游蛋白或传递信号。此外,据报道,DSB 修复因子的相分离失调会促进多种疾病的发生。这篇综述不仅全面概述了 LLPS 在 DSB 修复中的新作用,还揭示了相分离与 DNA 损伤应答(DDR)相关的调控模式。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Phase separation in DNA double-strand break response.

DNA double-strand break (DSB) is the most dangerous type of DNA damage, which may lead to cell death or oncogenic mutations. Homologous recombination (HR) and nonhomologous end-joining (NHEJ) are two typical DSB repair mechanisms. Recently, many studies have revealed that liquid-liquid phase separation (LLPS) plays a pivotal role in DSB repair and response. Through LLPS, the crucial biomolecules are quickly recruited to damaged sites with a high concentration to ensure DNA repair is conducted quickly and efficiently, which facilitates DSB repair factors activating downstream proteins or transmitting signals. In addition, the dysregulation of the DSB repair factor's phase separation has been reported to promote the development of a variety of diseases. This review not only provides a comprehensive overview of the emerging roles of LLPS in the repair of DSB but also sheds light on the regulatory patterns of phase separation in relation to the DNA damage response (DDR).

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