{"title":"艾滋病病毒感染者中血糖异常、血脂异常和代谢综合征的患病率：一项来自伊朗的横断面研究。","authors":"Marjan Shakiba, Shervin Shokouhi, Fariba Alaei, Amirreza Keyvanfar, Hanieh Najafiarab, Mehrdad Yasaei","doi":"10.47176/mjiri.37.115","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Human immunodeficiency virus (HIV) resulted in considerable morbidity and mortality. Following antiretroviral therapy (ART), the life expectancy of HIV-infected patients increased; however, they were more at risk of developing chronic diseases such as endocrinopathies. This study aimed to determine the prevalence of dysglycemia, dyslipidemia, and metabolic syndrome among patients with HIV infection.</p><p><strong>Methods: </strong>This cross-sectional study was conducted on HIV-infected patients referring to Loghman Hakim Hospital (Tehran, Iran) between April 2020 and April 2021. We examined demographic features, medical history, and laboratory tests indicating the metabolic status of the patients. Eventually, collected data were processed using SPSS version 23.</p><p><strong>Results: </strong>The mean age of 68 confirmed HIV patients was 39.85±10.54 years and 64.7% were male. BMI (MD = 2.57, 95% CI = [0.25, 4.88], <i>P</i> = 0.035), cholesterol (MD = 22.73, 95% CI = [4.70, 40.76], <i>P</i> = 0.014), HDL (MD = 8.54, 95% CI = [2.06, 15.02], <i>P</i> = 0.011), and LDL of women was significantly higher than men (MD = 22.43, 95% CI = [7.60, 37.27], <i>P</i> = 0.004). Additionally, 30 patients (44.1%) suffered from metabolic syndrome. The prevalence of metabolic syndrome differed significantly between men (34.1%) and women (62.50%) (<i>P</i> = 0.024).</p><p><strong>Conclusion: </strong>Dysglycemia, dyslipidemia, and metabolic syndrome are common among HIV-infected patients. Thus, periodic evaluation of the patients can be advantageous in early diagnosis and timely treatment.</p>","PeriodicalId":18361,"journal":{"name":"Medical Journal of the Islamic Republic of Iran","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10744192/pdf/","citationCount":"0","resultStr":"{\"title\":\"Prevalence of Dysglycemia, Dyslipidemia, and Metabolic Syndrome among Patients with HIV Infection: a Cross-sectional Study from Iran.\",\"authors\":\"Marjan Shakiba, Shervin Shokouhi, Fariba Alaei, Amirreza Keyvanfar, Hanieh Najafiarab, Mehrdad Yasaei\",\"doi\":\"10.47176/mjiri.37.115\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Human immunodeficiency virus (HIV) resulted in considerable morbidity and mortality. Following antiretroviral therapy (ART), the life expectancy of HIV-infected patients increased; however, they were more at risk of developing chronic diseases such as endocrinopathies. This study aimed to determine the prevalence of dysglycemia, dyslipidemia, and metabolic syndrome among patients with HIV infection.</p><p><strong>Methods: </strong>This cross-sectional study was conducted on HIV-infected patients referring to Loghman Hakim Hospital (Tehran, Iran) between April 2020 and April 2021. We examined demographic features, medical history, and laboratory tests indicating the metabolic status of the patients. Eventually, collected data were processed using SPSS version 23.</p><p><strong>Results: </strong>The mean age of 68 confirmed HIV patients was 39.85±10.54 years and 64.7% were male. BMI (MD = 2.57, 95% CI = [0.25, 4.88], <i>P</i> = 0.035), cholesterol (MD = 22.73, 95% CI = [4.70, 40.76], <i>P</i> = 0.014), HDL (MD = 8.54, 95% CI = [2.06, 15.02], <i>P</i> = 0.011), and LDL of women was significantly higher than men (MD = 22.43, 95% CI = [7.60, 37.27], <i>P</i> = 0.004). Additionally, 30 patients (44.1%) suffered from metabolic syndrome. The prevalence of metabolic syndrome differed significantly between men (34.1%) and women (62.50%) (<i>P</i> = 0.024).</p><p><strong>Conclusion: </strong>Dysglycemia, dyslipidemia, and metabolic syndrome are common among HIV-infected patients. Thus, periodic evaluation of the patients can be advantageous in early diagnosis and timely treatment.</p>\",\"PeriodicalId\":18361,\"journal\":{\"name\":\"Medical Journal of the Islamic Republic of Iran\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-10-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10744192/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medical Journal of the Islamic Republic of Iran\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.47176/mjiri.37.115\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical Journal of the Islamic Republic of Iran","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.47176/mjiri.37.115","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
摘要
背景：人类免疫缺陷病毒（HIV）导致了相当高的发病率和死亡率。经过抗逆转录病毒疗法（ART）治疗后，HIV 感染者的预期寿命延长了，但他们患慢性疾病（如内分泌疾病）的风险却增加了。本研究旨在确定 HIV 感染者中血糖异常、血脂异常和代谢综合征的发病率：这项横断面研究的对象是 2020 年 4 月至 2021 年 4 月期间转诊到 Loghman Hakim 医院（伊朗德黑兰）的 HIV 感染者。我们研究了人口统计学特征、病史和表明患者代谢状况的实验室检查。最终，我们使用 SPSS 23 版本对收集到的数据进行了处理：68名确诊的艾滋病患者的平均年龄为（39.85±10.54）岁，64.7%为男性。女性的体重指数（MD = 2.57，95% CI = [0.25，4.88]，P = 0.035）、胆固醇（MD = 22.73，95% CI = [4.70，40.76]，P = 0.014）、高密度脂蛋白（MD = 8.54，95% CI = [2.06，15.02]，P = 0.011）和低密度脂蛋白明显高于男性（MD = 22.43，95% CI = [7.60，37.27]，P = 0.004）。此外，30 名患者（44.1%）患有代谢综合征。男性（34.1%）和女性（62.50%）的代谢综合征患病率有显著差异（P = 0.024）：结论：血糖异常、血脂异常和代谢综合征在艾滋病病毒感染者中很常见。因此，对患者进行定期评估有利于早期诊断和及时治疗。
Prevalence of Dysglycemia, Dyslipidemia, and Metabolic Syndrome among Patients with HIV Infection: a Cross-sectional Study from Iran.
Background: Human immunodeficiency virus (HIV) resulted in considerable morbidity and mortality. Following antiretroviral therapy (ART), the life expectancy of HIV-infected patients increased; however, they were more at risk of developing chronic diseases such as endocrinopathies. This study aimed to determine the prevalence of dysglycemia, dyslipidemia, and metabolic syndrome among patients with HIV infection.
Methods: This cross-sectional study was conducted on HIV-infected patients referring to Loghman Hakim Hospital (Tehran, Iran) between April 2020 and April 2021. We examined demographic features, medical history, and laboratory tests indicating the metabolic status of the patients. Eventually, collected data were processed using SPSS version 23.
Results: The mean age of 68 confirmed HIV patients was 39.85±10.54 years and 64.7% were male. BMI (MD = 2.57, 95% CI = [0.25, 4.88], P = 0.035), cholesterol (MD = 22.73, 95% CI = [4.70, 40.76], P = 0.014), HDL (MD = 8.54, 95% CI = [2.06, 15.02], P = 0.011), and LDL of women was significantly higher than men (MD = 22.43, 95% CI = [7.60, 37.27], P = 0.004). Additionally, 30 patients (44.1%) suffered from metabolic syndrome. The prevalence of metabolic syndrome differed significantly between men (34.1%) and women (62.50%) (P = 0.024).
Conclusion: Dysglycemia, dyslipidemia, and metabolic syndrome are common among HIV-infected patients. Thus, periodic evaluation of the patients can be advantageous in early diagnosis and timely treatment.
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