实验性诱发兔颅骨缺损的骨质生成能力

Q2 Biochemistry, Genetics and Molecular Biology
Alkın Ünsal, Ercan Durmuş, İlhami Çelik
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引用次数: 0

摘要

背景:自体骨移植是颌面外科手术中用作移植材料的金标准。然而,从供体部位获得的这些材料数量有限,而且还需要更大的手术区域和二次手术,这经常导致移植骨的不可靠结合、牙齿强直和牙根吸收。因此,新的骨移植替代物应运而生,其中蛋壳粉被引入作为骨替代物。本研究旨在评估未加工、CMC涂层和明胶涂层鸵鸟蛋壳颗粒的生物相容性、吸收动力学和骨诱导性:每只动物都有四个半厚度的腓骨缺损。方法:为每只动物制作四个半厚度的腓骨缺损,在第1个月和第3个月结束时,通过临床、组织学、放射学和组织形态学方法对缺损部位进行检查:结果:在蛋壳颗粒上涂抹 CMC 和明胶有利于手术应用,并有助于新骨形成。然而,与未加工的蛋壳颗粒相比,它们在第 3 个月的新骨形成率较低。在骨建模过程中,CMC涂层比明胶涂层更有效:结论:鸵鸟蛋壳颗粒原形或涂覆 CMC 均可用作骨填充物,支持骨缺损治疗中的新骨形成和愈合。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Osteoproductivity in Experimentally Induced Cranial Bone Defects in Rabbits.

Background: Autogenous bone grafts are the gold standard for being used as graft materials in maxillofacial surgery. However, a limited amount of these materials is available from the donor site, and there is also more need for a larger operating area and a second surgery, which frequently leads to unreliable graft incorporation, tooth ankylosis, and root resorption. Therefore, newer bone graft substitutes have been developed as alternatives, among which eggshell powder has been introduced as a bone substitute. This study aimed to evaluate the biocompatibility, resorption kinetics, and osteoproductivity of the unprocessed, CMC-coated, and gelatin-coated ostrich eggshell particles.

Methods: Four half-thickness calvarial defects were created in each animal. At the end of the 1st and 3rd months, the defected sites were investigated by clinical, histological, radiological and histomorphometrical methods.

Results: Coating the eggshell particles with CMC and gelatin facilitated their surgical application and contributed to new bone formation. However, their newly formed bone rate at the 3rd month was lower than those of the unprocessed eggshell particles. The CMC coating was more effective than gelatin coating in the bone modeling process.

Conclusion: Ostrich eggshell particles either in native form or coated with CMC could be used as a bone filler for supporting new bone formation and healing in treatment of osseous defects.

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来源期刊
Iranian Biomedical Journal
Iranian Biomedical Journal Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
3.20
自引率
0.00%
发文量
42
审稿时长
8 weeks
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