环境变异和遗传多样性导致人群对 SARS-CoV-2 和 COVID-19 风险的免疫反应存在差异

IF 5 3区 医学 Q1 GENETICS & HEREDITY
Maxime Rotival, Lluis Quintana-Murci
{"title":"环境变异和遗传多样性导致人群对 SARS-CoV-2 和 COVID-19 风险的免疫反应存在差异","authors":"Maxime Rotival, Lluis Quintana-Murci","doi":"10.1038/s41435-023-00249-0","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":12691,"journal":{"name":"Genes and immunity","volume":"25 4","pages":"338-340"},"PeriodicalIF":5.0000,"publicationDate":"2023-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Environmental variation and genetic diversity contribute to population differences in immune responses to SARS-CoV-2 and COVID-19 risk\",\"authors\":\"Maxime Rotival, Lluis Quintana-Murci\",\"doi\":\"10.1038/s41435-023-00249-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\",\"PeriodicalId\":12691,\"journal\":{\"name\":\"Genes and immunity\",\"volume\":\"25 4\",\"pages\":\"338-340\"},\"PeriodicalIF\":5.0000,\"publicationDate\":\"2023-12-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Genes and immunity\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.nature.com/articles/s41435-023-00249-0\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"GENETICS & HEREDITY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Genes and immunity","FirstCategoryId":"3","ListUrlMain":"https://www.nature.com/articles/s41435-023-00249-0","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
引用次数: 0

摘要

COVID-19 大流行揭示了感染 SARS-CoV-2 的个体之间存在着相当大的临床差异,从无症状病例到致命结局不等[1]。影响这种差异的因素包括高龄、男性、合并症和人类遗传学[1, 2]。具体而言,针对 I 型干扰素(IFNs)的先天性错误或自身抗体已被确定为导致 COVID-19 肺炎严重程度的重要因素 [2]。此外,涉及 20 多万病例和 300 多万对照的全基因组关联研究(GWAS)确定了 51 个与 SARS-CoV-2 感染易感性或 COVID-19 严重程度相关的不同基因位点,强调了人类遗传因素在该疾病病理生理学中的重要作用[3]。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Environmental variation and genetic diversity contribute to population differences in immune responses to SARS-CoV-2 and COVID-19 risk

Environmental variation and genetic diversity contribute to population differences in immune responses to SARS-CoV-2 and COVID-19 risk

Environmental variation and genetic diversity contribute to population differences in immune responses to SARS-CoV-2 and COVID-19 risk
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Genes and immunity
Genes and immunity 医学-免疫学
CiteScore
8.90
自引率
4.00%
发文量
28
审稿时长
6-12 weeks
期刊介绍: Genes & Immunity emphasizes studies investigating how genetic, genomic and functional variations affect immune cells and the immune system, and associated processes in the regulation of health and disease. It further highlights articles on the transcriptional and posttranslational control of gene products involved in signaling pathways regulating immune cells, and protective and destructive immune responses.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信