血清磷脂脂肪酸与 4 岁健康儿童的骨量有关。

IF 3
Malin Garemo , Valter Sundh , Dan Mellström , Birgitta Strandvik
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引用次数: 0

摘要

背景脂肪酸参与骨骼发育,但对儿童的了解有限。本研究的目的是调查健康学龄前儿童的骨量和矿物质密度与脂肪酸的关系。材料和方法 111 名 4 岁健康儿童(20% 超重)的骨骼通过双 X 射线吸收测定法进行分析,血清磷脂脂肪酸通过气相色谱法进行分析。结果体重正常儿童的总骨质含量(BMC)和矿物质密度(BMD)因性别而异,但超重儿童的骨质密度普遍高于体重正常的儿童。在体重正常的儿童中,亚油酸摄入量与骨密度和股骨骨密度密切相关。血清中二十二碳六烯酸的浓度与所有儿童的骨密度均呈正相关(P=0.01),但亚油酸、花生四烯酸和单不饱和脂肪酸与体重正常儿童和超重儿童骨骼的相关性不同。结论血清磷脂 DHA 与骨密度有关,其他脂肪酸与骨骼部位的关系在超重儿童中有所不同,这与 8 岁健康儿童的情况类似。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Serum phospholipid fatty acids are associated with bone mass in healthy 4-years-old children

Background

Fatty acids are involved in bone development but knowledge in children is limited. The aim of this study was to investigate bone mass and mineral density in healthy preschool children in relation to fatty acids.

Material and methods

In 111 healthy 4-yrs-old children (20 % overweight) bone was analysed by dual X-ray absorptiometry and serum phospholipid fatty acid by gas chromatography. Fat intake was calculated from 7 days self-reported dietary records and food frequency questionnaire.

Results

Total bone mass content (BMC) and mineral density (BMD) differed by sex in normal weight, but not in overweight children showing generally higher bone mass density than children with normal weight. Linoleic acid intake was strongly correlated to BMC and femoral BMD in normal weight children. Serum concentration of docosahexaenoic acid correlated positively to BMD in all children (p = 0.01), but linoleic and arachidonic acids, and monounsaturated fatty acids showed diverging associations with bone in normal weight and overweight children.

Conclusion

Serum phospholipid DHA was associated with bone density. Other fatty acids associations to bone sites differed in overweight children, analogue to the pattern in healthy 8-yrs-old.The finding need to be confirmed longitudinally and in a larger group of overweight individuals.

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来源期刊
Prostaglandins, leukotrienes, and essential fatty acids
Prostaglandins, leukotrienes, and essential fatty acids Clinical Biochemistry, Endocrinology, Diabetes and Metabolism
CiteScore
5.30
自引率
0.00%
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审稿时长
64 days
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