Nibedita Priyadarsini, Devineni Likhitha, Madumathy Ramachandran, Kishore Kumar Behera
{"title":"心迷走神经活动受损是印度东部人群中 2 型糖尿病患者高血糖与动脉僵化之间的联系:一项横断面研究。","authors":"Nibedita Priyadarsini, Devineni Likhitha, Madumathy Ramachandran, Kishore Kumar Behera","doi":"10.1016/j.jcjd.2023.12.003","DOIUrl":null,"url":null,"abstract":"<h3>Introduction</h3><p>Cardiac autonomic neuropathy (CAN) is one of the most common yet overlooked complications in Type- 2 Diabetes mellitus (T2DM). The T2DM patients with CAN show a fivefold increase in Cardiovascular morbidity and mortality. The presence of CAN in T2DM could potentially lead to arterial stiffness. However, there is sparse data available to prove this association between autonomic dysfunction and arterial stiffness in T2DM.</p><h3>Methods</h3><p>We recruited 80 T2DM patients and 74 healthy controls. Heart rate variability (HRV) was done to assess autonomic function. The assessment of arterial stiffness was done by measuring brachial Pulse wave velocity (baPWV) and Augmentation index (AI).</p><h3>Results</h3><p>The time domain parameters were significantly decreased (<em>P</em><0.001) and frequency domain parameters like total power and HFnu were found to be significantly reduced in T2DM patients (<em>P</em><0.001). The baPWV and AI were significantly higher in T2DM compared to healthy controls (<em>P</em><0.001). We observed a moderate correlation between SDNN and baPWV (r= -0.437, <em>P</em> 0.002) and AI (r= -0.403, <em>P</em> 0.002). The multiple linear regression model shows an association between SDNN and arterial stiffness parameters like baPWV and AI which was statistically significant (p<0.05) in the fully adjusted model which includes the conventional risk factors for atherosclerosis.</p><h3>Conclusion</h3><p>The impaired cardiovagal activity is an independent risk factor for the development of arterial stiffness. Incorporation of HRV test into diabetes management protocol will have potential benefits of identifying the patients at high risk of developing cardiovascular events. Hence, preventive measures can be taken at the earliest to improve patient outcomes.</p>","PeriodicalId":9565,"journal":{"name":"Canadian Journal of Diabetes","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Impaired cardiovagal activity as a link between hyperglycemia and arterial stiffness in type-2 diabetes mellitus patients among Eastern Indian population: A cross-sectional study.\",\"authors\":\"Nibedita Priyadarsini, Devineni Likhitha, Madumathy Ramachandran, Kishore Kumar Behera\",\"doi\":\"10.1016/j.jcjd.2023.12.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3>Introduction</h3><p>Cardiac autonomic neuropathy (CAN) is one of the most common yet overlooked complications in Type- 2 Diabetes mellitus (T2DM). The T2DM patients with CAN show a fivefold increase in Cardiovascular morbidity and mortality. The presence of CAN in T2DM could potentially lead to arterial stiffness. However, there is sparse data available to prove this association between autonomic dysfunction and arterial stiffness in T2DM.</p><h3>Methods</h3><p>We recruited 80 T2DM patients and 74 healthy controls. Heart rate variability (HRV) was done to assess autonomic function. The assessment of arterial stiffness was done by measuring brachial Pulse wave velocity (baPWV) and Augmentation index (AI).</p><h3>Results</h3><p>The time domain parameters were significantly decreased (<em>P</em><0.001) and frequency domain parameters like total power and HFnu were found to be significantly reduced in T2DM patients (<em>P</em><0.001). The baPWV and AI were significantly higher in T2DM compared to healthy controls (<em>P</em><0.001). We observed a moderate correlation between SDNN and baPWV (r= -0.437, <em>P</em> 0.002) and AI (r= -0.403, <em>P</em> 0.002). 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Impaired cardiovagal activity as a link between hyperglycemia and arterial stiffness in type-2 diabetes mellitus patients among Eastern Indian population: A cross-sectional study.
Introduction
Cardiac autonomic neuropathy (CAN) is one of the most common yet overlooked complications in Type- 2 Diabetes mellitus (T2DM). The T2DM patients with CAN show a fivefold increase in Cardiovascular morbidity and mortality. The presence of CAN in T2DM could potentially lead to arterial stiffness. However, there is sparse data available to prove this association between autonomic dysfunction and arterial stiffness in T2DM.
Methods
We recruited 80 T2DM patients and 74 healthy controls. Heart rate variability (HRV) was done to assess autonomic function. The assessment of arterial stiffness was done by measuring brachial Pulse wave velocity (baPWV) and Augmentation index (AI).
Results
The time domain parameters were significantly decreased (P<0.001) and frequency domain parameters like total power and HFnu were found to be significantly reduced in T2DM patients (P<0.001). The baPWV and AI were significantly higher in T2DM compared to healthy controls (P<0.001). We observed a moderate correlation between SDNN and baPWV (r= -0.437, P 0.002) and AI (r= -0.403, P 0.002). The multiple linear regression model shows an association between SDNN and arterial stiffness parameters like baPWV and AI which was statistically significant (p<0.05) in the fully adjusted model which includes the conventional risk factors for atherosclerosis.
Conclusion
The impaired cardiovagal activity is an independent risk factor for the development of arterial stiffness. Incorporation of HRV test into diabetes management protocol will have potential benefits of identifying the patients at high risk of developing cardiovascular events. Hence, preventive measures can be taken at the earliest to improve patient outcomes.
期刊介绍:
The Canadian Journal of Diabetes is Canada''s only diabetes-oriented, peer-reviewed, interdisciplinary journal for diabetes health-care professionals.
Published bimonthly, the Canadian Journal of Diabetes contains original articles; reviews; case reports; shorter articles such as Perspectives in Practice, Practical Diabetes and Innovations in Diabetes Care; Diabetes Dilemmas and Letters to the Editor.