剧烈运动与适度运动改善多囊卵巢综合征和胰岛素抵抗不活跃妇女的葡萄糖代谢：两种家庭锻炼方法的试点随机对照试验

FS Reports Pub Date : 2024-03-01 DOI:10.1016/j.xfre.2023.12.004

Ange Wang M.D. , Martha Noel M.D. , Jacob P. Christ M.D. , Jamie Corley B.S. , Nikolaus Lenhart B.S. , Marcelle I. Cedars M.D. , Heather Huddleston M.D.

{"title":"剧烈运动与适度运动改善多囊卵巢综合征和胰岛素抵抗不活跃妇女的葡萄糖代谢：两种家庭锻炼方法的试点随机对照试验","authors":"Ange Wang M.D. , Martha Noel M.D. , Jacob P. Christ M.D. , Jamie Corley B.S. , Nikolaus Lenhart B.S. , Marcelle I. Cedars M.D. , Heather Huddleston M.D.","doi":"10.1016/j.xfre.2023.12.004","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>To study the impact of vigorous vs. moderate exercise on metabolic parameters in polycystic ovary syndrome (PCOS).</p></div><div><h3>Design</h3><p>Randomized controlled trial.</p></div><div><h3>Setting</h3><p>Unsupervised home-based exercise program.</p></div><div><h3>Patient(s)</h3><p>Patients with PCOS on the basis of the Rotterdam criteria with insulin resistance.</p></div><div><h3>Intervention(s)</h3><p>Participants were block randomized to a home-based exercise program of 75 minutes of vigorous exercise or 150 minutes of moderate exercise per week, for 8 weeks total.</p></div><div><h3>Main Outcome Measure(s)</h3><p>Changes in glucose, insulin, and insulin resistance.</p></div><div><h3>Result(s)</h3><p>In total, 36 participants were randomized, of whom 20 completed the study. The percentage changes from baseline at 4 and 8 weeks for fasting glucose, insulin, and homeostatic model assessment for insulin resistance did not significantly differ between the groups, except for the change in the 8-week glucose level, which was more favorable in the moderate arm (8.06% [standard deviation, 6.44%] in the vigorous group compared with −0.32% [standard deviation, 4.91%] in the moderate group). The absolute values of the main outcomes (fasting glucose, insulin, and homeostatic model assessment for insulin resistance) at baseline and 4 and 8 weeks did not significantly differ between trial arms. When assessing the change from baseline at 4 and 8 weeks, overall and within each trial arm, only the 8-week fasting glucose level was significantly greater than the baseline value in the vigorous arm (93.5 [95% confidence interval, 88.7–98.3] vs. 86.8 [95% confidence interval, 81.1–92.4]).</p></div><div><h3>Conclusion(s)</h3><p>Unsupervised short-term exercise programs may not achieve significant metabolic improvements in patients with PCOS, regardless of vigorous vs. moderate intensity. Future studies should investigate this question in larger sample sizes and longer or structured exercise programs.</p></div><div><h3>Clinical Trial Registration Number</h3><p>ClinicalTrials.gov identifier, NCT02303470.</p></div>","PeriodicalId":34409,"journal":{"name":"FS Reports","volume":"5 1","pages":"Pages 80-86"},"PeriodicalIF":0.0000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666334123001368/pdfft?md5=d55d2acb2f1aebad5a44be19a009a4a7&pid=1-s2.0-S2666334123001368-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Vigorous vs. moderate exercise to improve glucose metabolism in inactive women with polycystic ovary syndrome and insulin resistance: a pilot randomized controlled trial of two home-based exercise routines\",\"authors\":\"Ange Wang M.D. , Martha Noel M.D. , Jacob P. Christ M.D. , Jamie Corley B.S. , Nikolaus Lenhart B.S. , Marcelle I. Cedars M.D. , Heather Huddleston M.D.\",\"doi\":\"10.1016/j.xfre.2023.12.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>To study the impact of vigorous vs. moderate exercise on metabolic parameters in polycystic ovary syndrome (PCOS).</p></div><div><h3>Design</h3><p>Randomized controlled trial.</p></div><div><h3>Setting</h3><p>Unsupervised home-based exercise program.</p></div><div><h3>Patient(s)</h3><p>Patients with PCOS on the basis of the Rotterdam criteria with insulin resistance.</p></div><div><h3>Intervention(s)</h3><p>Participants were block randomized to a home-based exercise program of 75 minutes of vigorous exercise or 150 minutes of moderate exercise per week, for 8 weeks total.</p></div><div><h3>Main Outcome Measure(s)</h3><p>Changes in glucose, insulin, and insulin resistance.</p></div><div><h3>Result(s)</h3><p>In total, 36 participants were randomized, of whom 20 completed the study. The percentage changes from baseline at 4 and 8 weeks for fasting glucose, insulin, and homeostatic model assessment for insulin resistance did not significantly differ between the groups, except for the change in the 8-week glucose level, which was more favorable in the moderate arm (8.06% [standard deviation, 6.44%] in the vigorous group compared with −0.32% [standard deviation, 4.91%] in the moderate group). The absolute values of the main outcomes (fasting glucose, insulin, and homeostatic model assessment for insulin resistance) at baseline and 4 and 8 weeks did not significantly differ between trial arms. When assessing the change from baseline at 4 and 8 weeks, overall and within each trial arm, only the 8-week fasting glucose level was significantly greater than the baseline value in the vigorous arm (93.5 [95% confidence interval, 88.7–98.3] vs. 86.8 [95% confidence interval, 81.1–92.4]).</p></div><div><h3>Conclusion(s)</h3><p>Unsupervised short-term exercise programs may not achieve significant metabolic improvements in patients with PCOS, regardless of vigorous vs. moderate intensity. Future studies should investigate this question in larger sample sizes and longer or structured exercise programs.</p></div><div><h3>Clinical Trial Registration Number</h3><p>ClinicalTrials.gov identifier, NCT02303470.</p></div>\",\"PeriodicalId\":34409,\"journal\":{\"name\":\"FS Reports\",\"volume\":\"5 1\",\"pages\":\"Pages 80-86\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2666334123001368/pdfft?md5=d55d2acb2f1aebad5a44be19a009a4a7&pid=1-s2.0-S2666334123001368-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"FS Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666334123001368\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"FS Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666334123001368","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

目的研究剧烈运动与适度运动对多囊卵巢综合征（PCOS）代谢参数的影响。主要结果指标：血糖、胰岛素和胰岛素抵抗的变化。结果：共有36名参与者被随机分配，其中20人完成了研究。4周和8周时，空腹血糖、胰岛素和胰岛素抵抗平衡模型评估值与基线相比的百分比变化在各组之间没有显著差异，只有8周血糖水平的变化在中度组更为有利（剧烈组为8.06%[标准偏差，6.44%]，而中度组为-0.32%[标准偏差，4.91%]）。不同试验组在基线、4 周和 8 周的主要结果（空腹血糖、胰岛素和胰岛素抵抗稳态模型评估）的绝对值没有显著差异。在评估4周和8周时与基线值相比的变化时，总体而言以及在每个试验组中，只有剧烈组的8周空腹血糖水平显著高于基线值（93.5 [95%置信区间，88.7-98.3] vs. 86.8 [95%置信区间，81.1-92.4]）。未来的研究应通过更大的样本量、更长的时间或结构化的锻炼计划来探讨这一问题。临床试验注册号ClinicalTrials.gov identifier，NCT02303470。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Vigorous vs. moderate exercise to improve glucose metabolism in inactive women with polycystic ovary syndrome and insulin resistance: a pilot randomized controlled trial of two home-based exercise routines

Objective

To study the impact of vigorous vs. moderate exercise on metabolic parameters in polycystic ovary syndrome (PCOS).

Design

Randomized controlled trial.

Setting

Unsupervised home-based exercise program.

Patient(s)

Patients with PCOS on the basis of the Rotterdam criteria with insulin resistance.

Intervention(s)

Participants were block randomized to a home-based exercise program of 75 minutes of vigorous exercise or 150 minutes of moderate exercise per week, for 8 weeks total.

Main Outcome Measure(s)

Changes in glucose, insulin, and insulin resistance.

Result(s)

In total, 36 participants were randomized, of whom 20 completed the study. The percentage changes from baseline at 4 and 8 weeks for fasting glucose, insulin, and homeostatic model assessment for insulin resistance did not significantly differ between the groups, except for the change in the 8-week glucose level, which was more favorable in the moderate arm (8.06% [standard deviation, 6.44%] in the vigorous group compared with −0.32% [standard deviation, 4.91%] in the moderate group). The absolute values of the main outcomes (fasting glucose, insulin, and homeostatic model assessment for insulin resistance) at baseline and 4 and 8 weeks did not significantly differ between trial arms. When assessing the change from baseline at 4 and 8 weeks, overall and within each trial arm, only the 8-week fasting glucose level was significantly greater than the baseline value in the vigorous arm (93.5 [95% confidence interval, 88.7–98.3] vs. 86.8 [95% confidence interval, 81.1–92.4]).

Conclusion(s)

Unsupervised short-term exercise programs may not achieve significant metabolic improvements in patients with PCOS, regardless of vigorous vs. moderate intensity. Future studies should investigate this question in larger sample sizes and longer or structured exercise programs.