鸡蛋过敏症患者对加热鸡蛋的耐受性:对预防和治疗的解释和影响

IF 4.6 2区 医学 Q2 ALLERGY
Audrey Leau, Sandra Denery-Papini, Marie Bodinier, Wieneke Dijk
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引用次数: 0

摘要

摘要 母鸡蛋过敏是儿童中第二常见的食物过敏症。生鸡蛋或加热鸡蛋都可能引起过敏症状,但大多数鸡蛋过敏儿童都能耐受煮熟或烤熟的鸡蛋。了解对加热鸡蛋耐受的原因可为鸡蛋过敏的分子机制提供线索,加热鸡蛋和烤鸡蛋的不同过敏性可用于预防或治疗鸡蛋过敏。因此,在这篇综述中,我们将讨论:(i) 为什么有些患者能够耐受加热鸡蛋;通过强调蛋白 (EW) 蛋白在加热后的结构变化及其对免疫反应性的影响,以及患者的特征;(ii) 加热或烘焙 EW 在多大程度上可用于初级预防策略或口服免疫疗法。我们发现,对 EW 的免疫反应水平有助于区分患者对加热或烘烤鸡蛋的耐受性或反应性。此外,在一级预防策略中使用加热或烘烤的鸡蛋似乎很有效,并可限制不良反应。口服免疫疗法是一种很有前景的治疗策略,但有时会引起严重的不良反应。使用加热或烘烤的鸡蛋可能会限制这些不良反应,但目前的文献还不足以对其疗效做出结论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Tolerance to heated egg in egg allergy: Explanations and implications for prevention and treatment

Tolerance to heated egg in egg allergy: Explanations and implications for prevention and treatment

Hen's egg allergy is the second most frequent food allergy found in children. Allergic symptoms can be caused by raw or heated egg, but a majority of egg-allergic children can tolerate hard-boiled or baked egg. Understanding the reasons for the tolerance towards heated egg provides clues about the molecular mechanisms involved in egg allergy, and the differential allergenicity of heated and baked egg might be exploited to prevent or treat egg allergy. In this review, we therefore discuss (i) why some patients are able to tolerate heated egg; by highlighting the structural changes of egg white (EW) proteins upon heating and their impact on immunoreactivity, as well as patient characteristics, and (ii) to what extent heated or baked EW might be useful for primary prevention strategies or oral immunotherapy. We describe that the level of immunoreactivity towards EW helps to discriminate patients tolerant or reactive to heated or baked egg. Furthermore, the use of heated or baked egg seems effective in primary prevention strategies and might limit adverse reactions. Oral immunotherapy is a promising treatment strategy, but it can sometimes cause significant adverse events. The use of heated or baked egg might limit these, but current literature is insufficient to conclude about its efficacy.

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来源期刊
Clinical and Translational Allergy
Clinical and Translational Allergy Immunology and Microbiology-Immunology
CiteScore
7.50
自引率
4.50%
发文量
117
审稿时长
12 weeks
期刊介绍: Clinical and Translational Allergy, one of several journals in the portfolio of the European Academy of Allergy and Clinical Immunology, provides a platform for the dissemination of allergy research and reviews, as well as EAACI position papers, task force reports and guidelines, amongst an international scientific audience. Clinical and Translational Allergy accepts clinical and translational research in the following areas and other related topics: asthma, rhinitis, rhinosinusitis, drug hypersensitivity, allergic conjunctivitis, allergic skin diseases, atopic eczema, urticaria, angioedema, venom hypersensitivity, anaphylaxis, food allergy, immunotherapy, immune modulators and biologics, animal models of allergic disease, immune mechanisms, or any other topic related to allergic disease.
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