{"title":"从莸中提取的双萜类和虹彩类化合物","authors":"ZHANG Shanshan , MAO Xudong , XU Hongtao , WEI Xiaohui , CHOU Guixin","doi":"10.1016/S1875-5364(23)60409-1","DOIUrl":null,"url":null,"abstract":"<div><p>Six new abietane diterpenoids (<strong>1−6</strong>) and five undescribed iridoids (<strong>7−11</strong>) have been isolated from the aerial parts of <em>Caryopteris mongolica</em>. The intricate structural characterization of these compounds was meticulously undertaken using an array of advanced spectroscopic techniques. This process was further enhanced by the application of DP4+ probability analyses and electronic circular dichroism (ECD) calculations. Following isolation and structural elucidation, the cytotoxicity of these compounds was evaluated. Among them, compound <strong>3</strong> stood out, displaying significant cytotoxic activity against HeLa cells with an IC<sub>50</sub> value of 7.83 ± 1.28 μmol·L<sup>−1</sup>. Additionally, compounds <strong>1, 2, 4, 9</strong>, and <strong>10</strong> manifested moderate cytotoxic effects on specific cell lines, with IC<sub>50</sub> values ranging from 11.7 to 20.9 μmol·L<sup>−1</sup>.</p></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":null,"pages":null},"PeriodicalIF":4.0000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Abietane diterpenoids and iridoids from Caryopteris mongolica\",\"authors\":\"ZHANG Shanshan , MAO Xudong , XU Hongtao , WEI Xiaohui , CHOU Guixin\",\"doi\":\"10.1016/S1875-5364(23)60409-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Six new abietane diterpenoids (<strong>1−6</strong>) and five undescribed iridoids (<strong>7−11</strong>) have been isolated from the aerial parts of <em>Caryopteris mongolica</em>. The intricate structural characterization of these compounds was meticulously undertaken using an array of advanced spectroscopic techniques. This process was further enhanced by the application of DP4+ probability analyses and electronic circular dichroism (ECD) calculations. Following isolation and structural elucidation, the cytotoxicity of these compounds was evaluated. Among them, compound <strong>3</strong> stood out, displaying significant cytotoxic activity against HeLa cells with an IC<sub>50</sub> value of 7.83 ± 1.28 μmol·L<sup>−1</sup>. Additionally, compounds <strong>1, 2, 4, 9</strong>, and <strong>10</strong> manifested moderate cytotoxic effects on specific cell lines, with IC<sub>50</sub> values ranging from 11.7 to 20.9 μmol·L<sup>−1</sup>.</p></div>\",\"PeriodicalId\":10002,\"journal\":{\"name\":\"Chinese Journal of Natural Medicines\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2023-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chinese Journal of Natural Medicines\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1875536423604091\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"INTEGRATIVE & COMPLEMENTARY MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chinese Journal of Natural Medicines","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1875536423604091","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}
Abietane diterpenoids and iridoids from Caryopteris mongolica
Six new abietane diterpenoids (1−6) and five undescribed iridoids (7−11) have been isolated from the aerial parts of Caryopteris mongolica. The intricate structural characterization of these compounds was meticulously undertaken using an array of advanced spectroscopic techniques. This process was further enhanced by the application of DP4+ probability analyses and electronic circular dichroism (ECD) calculations. Following isolation and structural elucidation, the cytotoxicity of these compounds was evaluated. Among them, compound 3 stood out, displaying significant cytotoxic activity against HeLa cells with an IC50 value of 7.83 ± 1.28 μmol·L−1. Additionally, compounds 1, 2, 4, 9, and 10 manifested moderate cytotoxic effects on specific cell lines, with IC50 values ranging from 11.7 to 20.9 μmol·L−1.
期刊介绍：
The Chinese Journal of Natural Medicines (CJNM), founded and sponsored in May 2003 by China Pharmaceutical University and the Chinese Pharmaceutical Association, is devoted to communication among pharmaceutical and medical scientists interested in the advancement of Traditional Chinese Medicines (TCM). CJNM publishes articles relating to a broad spectrum of bioactive natural products, leading compounds and medicines derived from Traditional Chinese Medicines (TCM).
Topics covered by the journal are: Resources of Traditional Chinese Medicines; Interaction and complexity of prescription; Natural Products Chemistry (including structure modification, semi-and total synthesis, bio-transformation); Pharmacology of natural products and prescription (including pharmacokinetics and toxicology); Pharmaceutics and Analytical Methods of natural products.
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