大鼠肾上腺脂肪组织神经支配的形态特征

IF 1.5 0 LANGUAGE & LINGUISTICS

Morphology Pub Date : 2023-12-11 DOI:10.17816/morph.607423

Eugene Ivanovich Chumasov, E. S. Petrova, D. E. Korzhevskii

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引用次数: 0

摘要

背景：研究脂肪组织的意义在于缺乏对肥胖症病因和发病机制的了解，以及缺乏对脂肪组织内分泌功能的研究。关于肾上腺白色脂肪组织和棕色脂肪组织的结构、功能和神经支配特点的问题是研究最少的。目的：本研究旨在利用神经免疫组化标记研究大鼠肾上腺脂肪组织的结构和神经支配。方法：使用石蜡切片对 PGP 9.5 蛋白、酪氨酸羟化酶和突触素进行免疫组化反应，研究大鼠肾上腺脂肪组织的神经支配（n=10）。结果：在大鼠肾上腺的白色和棕色脂肪组织中发现了无髓鞘神经纤维以及儿茶酚胺能和胆碱能神经末梢装置。研究表明，副交感神经和交感神经节后神经纤维可通过动脉血管穿透脂肪组织。在那里，雷马科夫曲张轴突密集分支并形成终末突触网络，参与白色和棕色脂肪组织中脂肪细胞的神经支配。大部分交感和副交感神经突触结构位于棕色和混合脂肪组织中。交感神经纤维与动脉血管壁紧密相连，并与棕色脂肪细胞接触。在白色脂肪组织中，曲张轴突主要分布在动脉血管周围，很少出现在分化的环形脂肪细胞之间。结论：白色脂肪组织和棕色脂肪组织的交感神经支配之所以存在明显差异，是因为棕色脂肪组织细胞与白色脂肪细胞不同，具有分泌功能。它们通过分泌脂肪因子，影响肾上腺分泌皮质类固醇。研究结果表明，这一过程受交感神经系统控制

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Morphological features of the innervation of the rat adrenal gland adipose tissue

BACKGROUND: The relevance of studying adipose tissue is due to the lack of knowledge about the etiology and pathogenesis of obesity and the lack of research into the endocrine function of adipose tissue. Questions about the structure, functions, and innervation characteristics of white and brown adipose tissue of the adrenal gland are the least studied. AIM: The purpose of this study was to study the structure and innervation of rat adrenal adipose tissue using neuroimmunohistochemical markers. METHODS: Using immunohistochemical reactions for PGP 9.5 protein, tyrosine hydroxylase and synaptophysin, performed on paraffin sections, the innervation of the adipose tissue of the rat adrenal gland was studied (n=10). RESULTS: Unmyelinated nerve fibers, as well as catecholaminergic and cholinergic nerve terminal apparatuses, were identified in the white and brown adipose tissue of the rat adrenal gland. It has been shown that parasympathetic and sympathetic postganglionic nerve fibers penetrate adipose tissue through arterial vessels. There, Remakov's varicose axons intensively branch and form terminal synaptic networks of the en passant type, which are involved in the innervation of adipocytes in white and brown adipose tissue. Most sympathetic and parasympathetic synaptic structures are localized in brown and mixed adipose tissue. Sympathetic fibers are in close connection with the wall of arterial vessels and contact brown adipocytes. In white adipose tissue, varicose axons are found mainly around arterial vessels and are rarely found between differentiated ring-shaped adipocytes. CONCLUSION: The noted differences in the sympathetic innervation of white and brown adipose tissue are due to the fact that, unlike white adipocytes, brown adipose tissue cells perform a secretory function. By producing adipokines, they influence the production of corticosteroids by the adrenal gland. The findings suggest that this process is under the control of the sympathetic nervous system

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来源期刊

Morphology LANGUAGE & LINGUISTICS-

CiteScore

3.60

自引率

0.00%

发文量

期刊介绍： Aim The aim of Morphology is to publish high quality articles that contribute to the further articulation of morphological theory and linguistic theory in general, or present new and unexplored data. Relevant empirical evidence for the theoretical claims in the articles will be provided by in-depth analyses of specific languages or by comparative, cross-linguistic analyses of the relevant facts. The sources of data can be grammatical descriptions, corpora of data concerning language use and other naturalistic data, and experiments. Scope Morphology publishes articles on morphology proper, as well as articles on the interaction of morphology with phonology, syntax, and semantics, the acquisition and processing of morphological information, the nature of the mental lexicon, and morphological variation and change. Its main focus is on formal models of morphological knowledge, morphological typology (the range and limits of variation in natural languages), the position of morphology in the architecture of the human language faculty, and the evolution and change of language. In addition, the journal deals with the acquisition of morphological knowledge and its role in language processing. Articles on computational morphology and neurolinguistic approaches to morphology are also welcome. The first volume of Morphology appeared as Volume 16 (2006). Previous volumes were published under the title Yearbook of Morphology.