急性 ST 段抬高型心肌梗死患者的血小板计数与平均血小板体积的关系

Bangladesh Heart Journal Pub Date : 2023-12-12 DOI:10.3329/bhj.v38i2.70277

Md Shakur Ahmed, M. Uddin, Ummey Zahira Popy, Mohammad Mohammad Ali, Bishnu Pada Saha, Fahdia Afroz, M. Haque, Zahidul Islam Khan, Md Saiful Islam, Monwarul Haque Tohin, Nur Alam, Tariq Ahmed Choudhury, Md Wareshuzzaman, Iftekhar Alam

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引用次数: 0

摘要

背景：使用简单、快速、易得的工具进行早期预测和快速诊断是急性冠状动脉综合征（如 ST 段抬高型心肌梗死）早期治疗的重要组成部分。由于血小板在血栓形成过程中起着重要作用，而体积较大的血小板在血栓致病过程中更为活跃，因此血小板指数可作为急性冠脉综合征的早期预测指标。研究目的本研究旨在评估急性ST段抬高型心肌梗死患者的血小板计数和平均血小板体积（MPV）之间的关系：本观察性研究于 2019 年 11 月至 2020 年 10 月在孟加拉国达卡国家心血管疾病研究所（NICVD）心脏病学系进行。共有 166 名受试者参与了这项研究。其中82名受试者（I组）静息心电图显示为急性ST段抬高型心肌梗死，入住NICVD的CCU，之前没有服用抗血小板药物的病史；另外84名受试者（II组）作为对照组，12导联静息心电图正常，肌钙蛋白-I正常：结果：两组受试者的年龄无明显差异（P =0.063）。ST段抬高的心肌梗死受试者吸烟率和冠心病家族史明显更高（分别为 0.002 和 <0.001）。高血压、糖尿病和血脂异常等相关危险因素在 ST 升高型心肌梗死患者中明显较高（<0.001）。与对照组（258 X 109/L vs. 267 X109/L）相比，ST 升高型心肌梗死组的血小板计数无明显差异。与对照组相比，发现 I 组患者的平均血小板体积（MPV）较高（12.20±0.86 vs. 9.26±0.77），且差异显著（P <0.001）：结论：在急性ST段抬高型心肌梗死中，较高的平均血小板体积（MPV）和较低的血小板计数可能是一个有用的标志：120-126

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Association of Platelet Count and Mean Platelet Volume in Acute ST- Elevated Myocardial Infarction

Background: Early prediction and quick diagnosis with simple, quick and easily available tool is essential part of early management of acute coronary syndrome e.g. ST segment elevated myocardial infarction. As platelet has a significant role in thrombus formation and larger sized platelets are more active in thrombotic pathogenicity, as such platelet indices can be the early predictor for acute coronary syndrome. Objective: Aim of this study was to assess the association of platelet count and mean platelet volume (MPV) in acute ST-elevated myocardial infarction. Methodology: This observational study was conducted at the department of Cardiology of National Institute of Cardiovascular Diseases (NICVD), Dhaka, Bangladesh from November 2019 to October 2020. Total 166 subjects were enrolled in this study. Among them 82 subjects (Group I) had acute ST-elevated myocardial infarction on resting ECG were admitted at CCU of NICVD and without any prior history of anti-platelet drugs intake, another 84 subjects (Group II) were enrolled in this study as control group with normal 12 lead resting ECG with normal Troponin-I. Results: No significant age difference observed between two groups (p =0.063). Significantly higher smoking and family history of coronary artery disease observed with ST elevated MI subjects (p:0.002 and <0.001 respectively). Associated risk factors like hypertension, diabetes and dyslipidemia were significantly high (<0.001) in ST-elevated MI patients. No significant difference observed in platelet count between ST elevated MI groups compared with the control (258 X 109/L vs. 267 X109/L). Mean platelet volume (MPV) was found to be higher in group I patients as compared to control (12.20±0.86 vs. 9.26±0.77) and it was significant (p <0.001). Conclusion: In acute ST-elevated myocardial infraction, higher mean platelet volume (MPV) and lower platelet count may be a useful marker. Bangladesh Heart Journal 2023; 38(2): 120-126

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Bangladesh Heart Journal

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