{"title":"ALKBH5 基因多态性与江苏省中国儿童罹患神经母细胞瘤的风险","authors":"Qian Guan, Xinxin Zhang, Jiabin Liu, Chunlei Zhou, Jinhong Zhu, Haiyan Wu, Zhenjian Zhuo, Jing He","doi":"10.1002/cai2.103","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Neuroblastoma is one of the most common extracranial malignant solid tumors in children. AlkB homolog 5 (ALKBH5) is an RNA N6-methyladenosine (m6A) demethylase that plays a critical role in tumorigenesis and development. We assessed the association between single nucleotide polymorphisms (SNPs) in <i>ALKBH5</i> and the risk of neuroblastoma in a case-control study including 402 patients and 473 non-cancer controls.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Genotyping was determined by the TaqMan method. The association between <i>ALKBH5</i> polymorphisms (rs1378602 and rs8400) and the risk of neuroblastoma was evaluated using the odds ratio (OR) and 95% confidence interval (CI).</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>We found no strong association of <i>ALKBH5</i> rs1378602 and rs8400 with neuroblastoma risk. Further stratification analysis by age, sex, primary site, and clinical stage showed that the rs1378602 AG/AA genotype was associated with a lower risk of neuroblastoma in males (adjusted OR = 0.58, 95% CI = 0.35–0.97, <i>p</i> = 0.036) and children with retroperitoneal neuroblastoma (adjusted OR = 0.58, 95% CI = 0.34–0.98, <i>p</i> = 0.040).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p><i>ALKBH5</i> SNPs do not seem to be associated with neuroblastoma risk. More studies are required to confirm this negative result and reveal the relationship between gene polymorphisms of the m6A modifier <i>ALKBH5</i> and neuroblastoma.</p>\n </section>\n </div>","PeriodicalId":100212,"journal":{"name":"Cancer Innovation","volume":"3 2","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cai2.103","citationCount":"0","resultStr":"{\"title\":\"ALKBH5 gene polymorphisms and risk of neuroblastoma in Chinese children from Jiangsu Province\",\"authors\":\"Qian Guan, Xinxin Zhang, Jiabin Liu, Chunlei Zhou, Jinhong Zhu, Haiyan Wu, Zhenjian Zhuo, Jing He\",\"doi\":\"10.1002/cai2.103\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Neuroblastoma is one of the most common extracranial malignant solid tumors in children. AlkB homolog 5 (ALKBH5) is an RNA N6-methyladenosine (m6A) demethylase that plays a critical role in tumorigenesis and development. We assessed the association between single nucleotide polymorphisms (SNPs) in <i>ALKBH5</i> and the risk of neuroblastoma in a case-control study including 402 patients and 473 non-cancer controls.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>Genotyping was determined by the TaqMan method. The association between <i>ALKBH5</i> polymorphisms (rs1378602 and rs8400) and the risk of neuroblastoma was evaluated using the odds ratio (OR) and 95% confidence interval (CI).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>We found no strong association of <i>ALKBH5</i> rs1378602 and rs8400 with neuroblastoma risk. Further stratification analysis by age, sex, primary site, and clinical stage showed that the rs1378602 AG/AA genotype was associated with a lower risk of neuroblastoma in males (adjusted OR = 0.58, 95% CI = 0.35–0.97, <i>p</i> = 0.036) and children with retroperitoneal neuroblastoma (adjusted OR = 0.58, 95% CI = 0.34–0.98, <i>p</i> = 0.040).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p><i>ALKBH5</i> SNPs do not seem to be associated with neuroblastoma risk. More studies are required to confirm this negative result and reveal the relationship between gene polymorphisms of the m6A modifier <i>ALKBH5</i> and neuroblastoma.</p>\\n </section>\\n </div>\",\"PeriodicalId\":100212,\"journal\":{\"name\":\"Cancer Innovation\",\"volume\":\"3 2\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-12-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cai2.103\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cancer Innovation\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/cai2.103\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer Innovation","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cai2.103","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
神经母细胞瘤是儿童最常见的颅外恶性实体瘤之一。AlkB 同源物 5（ALKBH5）是一种 RNA N6-甲基腺苷（m6A）去甲基化酶，在肿瘤发生和发展过程中起着关键作用。我们在一项包括 402 名患者和 473 名非癌症对照者的病例对照研究中评估了 ALKBH5 中单核苷酸多态性（SNPs）与神经母细胞瘤风险之间的关联。我们发现，ALKBH5 rs1378602和rs8400与神经母细胞瘤的发病风险没有密切关系。根据年龄、性别、原发部位和临床分期进行的进一步分层分析表明，rs1378602 AG/AA 基因型与男性（调整后 OR = 0.58，95% CI = 0.35-0.97，p = 0.036）和腹膜后神经母细胞瘤患儿（调整后 OR = 0.58，95% CI = 0.34-0.98，p = 0.040）的神经母细胞瘤风险较低有关。ALKBH5的SNPs似乎与神经母细胞瘤的风险无关。需要更多的研究来证实这一阴性结果，并揭示m6A修饰因子ALKBH5的基因多态性与神经母细胞瘤之间的关系。
ALKBH5 gene polymorphisms and risk of neuroblastoma in Chinese children from Jiangsu Province
Background
Neuroblastoma is one of the most common extracranial malignant solid tumors in children. AlkB homolog 5 (ALKBH5) is an RNA N6-methyladenosine (m6A) demethylase that plays a critical role in tumorigenesis and development. We assessed the association between single nucleotide polymorphisms (SNPs) in ALKBH5 and the risk of neuroblastoma in a case-control study including 402 patients and 473 non-cancer controls.
Methods
Genotyping was determined by the TaqMan method. The association between ALKBH5 polymorphisms (rs1378602 and rs8400) and the risk of neuroblastoma was evaluated using the odds ratio (OR) and 95% confidence interval (CI).
Results
We found no strong association of ALKBH5 rs1378602 and rs8400 with neuroblastoma risk. Further stratification analysis by age, sex, primary site, and clinical stage showed that the rs1378602 AG/AA genotype was associated with a lower risk of neuroblastoma in males (adjusted OR = 0.58, 95% CI = 0.35–0.97, p = 0.036) and children with retroperitoneal neuroblastoma (adjusted OR = 0.58, 95% CI = 0.34–0.98, p = 0.040).
Conclusions
ALKBH5 SNPs do not seem to be associated with neuroblastoma risk. More studies are required to confirm this negative result and reveal the relationship between gene polymorphisms of the m6A modifier ALKBH5 and neuroblastoma.
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