微波合成的与磺酰胺分子融合的一些新吡啶衍生物的生物活性研究

IF 1.1 Q3 CHEMISTRY, MULTIDISCIPLINARY

Egyptian Journal of Chemistry Pub Date : 2023-12-01 DOI:10.21608/ejchem.2023.245709.8801

Islam Ragab, Rasha Abd El-Hady

引用次数: 0

摘要

在微波辐照下，吡啶 1a,b 与 3-氯丙醇、1,3-二氯异丙醇、环氧氯丙烷和溴乙酸甲酯发生烷基化反应，得到 N-(4-(5-氰基-6-(3-羟基丙氧基)-4-(4-异丙基苯基)吡啶-2-基)苯基)-4-甲基苯磺酰胺 (2a)、N-(4-(5-氰基-6-(3-羟基丙氧基)-4-(噻吩-2-基)吡啶-2-基)苯基)-4-甲基苯磺酰胺

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Study of the Biological Activity of Microwave Synthesized of some new Pyridine derivatives fused with Sulfonamide Moiety

Alkylation of pyridine 1a,b with 3-chloropropanol, 1,3-dichloroisopropanol, epichlorohydrin and methyl bromoacetate under microwave irradiation afforded N-(4-(5-cyano-6-(3-hydroxypropoxy)-4-(4-isopropylphenyl)pyridin-2-yl)phenyl)-4-methylbenzenesulfonamide (2a), N-(4-(5-cyano-6-(3-hydroxypropoxy)-4-(thiophen-2-yl)pyridin-2-yl)phenyl)-4-methylbenzenesulfonamide

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来源期刊

Egyptian Journal of Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

2.40

自引率

23.10%

发文量

977

期刊介绍： The Egyptian Journal of Chemistry is published bimonthly by the Egyptian Chemical Society. Contributions from fields of pure chemistry are invited. The fields includes general and physical chemistry, analytical and inorganic chemistry, organic and biological chemistry, and applied and materials chemistry.