叔丁氧羰基介导的 α-季均苯甲醛原醛脱羰基反应

IF 2 Q2 CHEMISTRY, ORGANIC
SynOpen Pub Date : 2023-12-18 DOI:10.1055/a-2231-3108
Ben Stokes, Xiaofeng Cai, Ritter V. Amsbaugh, Lauren J. Drake, Ravi M. A. Kotamraju, Nicholas Javier C. Licauco
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引用次数: 0

摘要

叔丁氧羰基化合物可在室温下介导容易获得的 α-季均苯甲醛和相关化合物的 Haller-Bauer 型(原醛化)脱羰基反应,生成囟代产物。宝石基二烷基和宝石基二芳基取代基都可以使用。宝石二甲基足以对多环烯丙基底物进行脱羰基反应,而单环芳香族均苯二甲醛则需要环状宝石二烷基或宝石二芳基才能进行显著的脱羰基反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

tert-Butoxide-Mediated Protodeformylative Decarbonylation of α-Quaternary Homobenzaldehydes

tert-Butoxide-Mediated Protodeformylative Decarbonylation of α-Quaternary Homobenzaldehydes
Tert-butoxide mediates the Haller–Bauer-type (protodeformylative) decarbonylation of readily accessed α-quaternary homobenzaldehydes and related compounds at room temperature, generating cumene products. Both geminal dialkyl and geminal diaryl substituents are tolerated. Gem-dimethyls are sufficient for decarbonylation of polycyclic arenyl substrates whereas monocyclic aromatic homobenzaldehydes require cyclic gem-dialkyls or gem-diaryls for significant decarbonylation.
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来源期刊
SynOpen
SynOpen CHEMISTRY, ORGANIC-
CiteScore
2.30
自引率
4.00%
发文量
35
审稿时长
6 weeks
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