A clinical investigation on the safety and effectiveness of an ayurvedic hair oil in controlling hair fall (khalitya) in healthy adult human subjects: a study on hair fall management

Background: Hair loss, commonly associated with genetics, hormones, or health conditions, is prevalent. Dandruff, resulting in flaky scalp skin, is also widespread. Ayurvedic herbal remedies show potential for addressing these hair issues. This clinical trial assesses the efficacy and safety of an ayurvedic hair oil in healthy adults with hair loss (alopecia). The aim is to evaluate its purported benefits in reducing hair fall, stimulating hair growth and alleviating scalp dandruff. Methods: This 8-week study involved 30 subjects with hair fall. After obtaining subject consent, a test hair oil was applied topically. Assessments included evaluating hair-fall, scalp dandruff, hair-growth rate, density, and thickness. Ayurvedic assessment determined hair type. Phototrichogram, pluck-test measured growth, with endpoints including pull-test, combing-test, dermatological evaluation, and subjective questionnaires. Statistical analysis used R software (Version: 4.1.2). Results: The study revealed significant therapeutic efficacy. The mean hair-growth rate increased significantly by 227µm/day (79.92±69.31%) over 8 weeks (p<0.01). Hair-fall decreased by 63.49±21.44%, from 97 to 31 hairs. Hair-thickness and density improved by 34.26±16.36% (p<0.01) and 39.82±34.3% (p<0.01) respectively. Scalp dandruff showed a reduction of 76.33±15.95% (p<0.01). The A:T ratio shifted positively from 3:1 to 5:1, indicating an increase in hairs in the anagen phase. No adverse effects were observed. Conclusions: Consistent use of 'moha: 5-in-1' hair oil over 8 weeks was well-tolerated and found effective. It significantly decreased hair fall, promoted hair growth, and improved scalp health by reducing dandruff. This confirms its safety and efficacy among study participants, establishing it as suitable choice for holistic daily hair care.