生物聚合物(蛋白质)如何折叠成独特的三维结构?

K. V. Shaitan
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引用次数: 0

摘要

讨论了蛋白质和其他生物聚合物折叠问题的现状。考虑到构型空间的拓扑结构以及相同单体单元排列对称元素的存在,详细介绍了线性高分子的多维势能面和自由能面的概念。在粘性介质中存在构象移动的运动键,导致线性聚合物倾向于形成螺旋结构。粘度的动态效应还导致能量耗散率在链节点上几乎均匀分布。势能表面形貌和粘度效应的结合为折叠理论的发展提供了物理基础,其方向是解释各种实验观察结果和阐明三维蛋白质结构氨基酸代码的形成原理。分析了生物聚合物折叠状态的变性温度与链中单体间非价相互作用能量之间的关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
How does a biopolymer (protein) fold into a unique 3D structure?
The current state of the problem of folding proteins and other biopolymers is discussed. The concept of a multidimensional potential energy surface and a free energy surface for linear polymers is detailed, taking into account the topology of the configuration space and the presence of symmetry elements with respect to the permutation of identical monomer units. The presence of kinematic bonds for conformational movements in a viscous medium leads to a tendency to form helical structures of linear polymers. The dynamic effects of viscosity also lead to an almost uniform distribution of energy dissipation rates over the chain nodes. The combination of potential energy surface topography and viscosity effects provides a physical basis for the development of the theory of folding in the direction of interpreting various experimental observations and elucidating the principles for the formation of an amino acid code for 3D protein structures. The relationship between the denaturation temperature of the folded state of the biopolymer and the energy of non-valent interactions between monomers in the chain is analyzed.
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