评估脱敏患者运动诱发试验期间外周嗜碱性粒细胞的激活情况

IF 3.3 Q2 ALLERGY

Frontiers in allergy Pub Date : 2023-12-22 DOI:10.3389/falgy.2023.1298137

Jun Kunizaki, Shiro Sugiura, Akira Sakai, Miyuki Teshigawara, Atsushi Makino, Y. Takasato, T. Matsui, Yasuto Kondo, K. Ito

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引用次数: 0

摘要

一些接受过口服免疫疗法的食物过敏患者会出现运动诱发的脱敏过敏反应（EIARDs）。本研究调查了为诊断 EIARD 而进行的运动诱发试验（EPT）期间嗜碱性粒细胞的活化状态。对 20 名参与者进行了 EPT，并使用活化标记 CD203c 和 CD63 分析了体内嗜碱性粒细胞的活化状态。结果显示，在整个 EPT 过程中，EPT 阳性和阴性受试者的嗜碱性粒细胞活化状态没有明显差异。因此，摄入致病食物后体内嗜碱性粒细胞的活化可能与 EIARDs 无关。我们需要新的检测方法来预测 EIARDs。

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Evaluation of peripheral basophil activation during exercise provocation test for desensitized patients

Some food allergic patients who have undergone oral immunotherapy develop exercise-induced allergic reactions on desensitization (EIARDs). This study investigated basophil activation status during the exercise provocation test (EPT) performed to diagnose EIARD. EPT was performed on 20 participants, and in vivo basophil activation status was analyzed using activation markers CD203c and CD63. The results showed that there was no significant difference between EPT-positive and negative subjects for basophil activation status throughout EPT. Consequently, in vivo basophil activation after ingestion of the causative food may not be associated with EIARDs. New tests are desired for predicting EIARDs.

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来源期刊

Frontiers in allergy

CiteScore

2.80

自引率

0.00%

发文量

审稿时长

12 weeks