111In 放射性核素治疗 S 值的蒙特卡罗研究

Masoud Jabbari, S. Pandesha
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引用次数: 0

摘要

放射性核素疗法中的新型治疗策略是利用细胞穿透单克隆抗体将奥杰辐射放射性核素带入细胞。估算正常细胞和肿瘤细胞的剂量对于研究治疗的有效性和毒性非常重要。蒙特卡洛模拟是在微观层面估算吸收剂量的最合适方法。因此,对奥杰辐射放射性核素进行蒙特卡罗模拟,以评估结果对蒙特卡罗代码中通常使用的传输近似值的敏感性,是非常有用的。 有几种奥杰辐射放射性核素具有潜在的临床应用价值,但根据其半衰期,111In 是最适合用于奥杰治疗的放射性核素,因此在本次研究中被考虑在内。利用不同的物理模型(标准模型、利弗莫尔模型、佩内洛普模型和 Geant4-DNA 模型)对 111In 进行了 Geant4 蒙特卡罗模拟,并计算了其特定吸收剂量分数(或 S 值),然后与医用内部辐射剂量学(MIRD)S 值进行了比较。辐射源分布在细胞质(Cy)、表面(Cs)和细胞核(N)。计算自吸收剂量和交叉吸收剂量的平均相对差值 (RD)(%)。标准、佩内洛普、利弗莫尔和 Geant4-DNA 的自身吸收(NßN)相对差值(%)分别为 4.4、2.36、6.21 和 1.1。交叉吸收的数值更高(例如,标准、Penelope、Livermore 和 Geant4-DNA 的 NßCy 分别为 15.4、18.36、19.21 和 24.8)。电子和伽马光子的截止能量会影响蒙特卡洛模拟中奥格电子的剂量估算结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Monte Carlo investigation of S-values for 111In radionuclide therapy
Novel therapeutic strategy in radionuclide therapy use cell-penetrating monoclonal antibodies to carry Auger-emitting radionuclides into the cells. Estimation of dose in normal and tumor cells are important to investigate the efficacy and toxicity of treatment. Monte Carlo simulation is the most suitable method for estimation of absorbed dose at microscopic level. It is therefore useful to carry out Monte Carlo simulation of Auger emitting radionuclides in order to assess the sensitivity of the results with respect to transport approximations generally used in Monte Carlo codes.   There are several Auger emitting radionuclides with potential clinical applications, however, based on their half-life 111In is the most suitable for Auger therapeutic purposes and was considered in the present investigation. Geant4 Monte Carlo simulation was performed and specific absorbed dose fraction (or S-values) for 111In were calculated by using different physics model (Standard, Livermore, Penelope and Geant4-DNA) and compared with Medical Internal Radiation Dosimetry (MIRD) S-values. Source was distributed in the cytoplasm (Cy), surface (Cs) and nucleus (N). Average of relative differences (RD) (%) were calculated for self and cross absorbed dose. RD(%) for self-absorption (NßN) were 4.4, 2.36, 6.21 and 1.1 for Standard, Penelope, Livermore and Geant4-DNA respectively. For cross-absorption these values were higher (e.g. for NßCy 15.4, 18.36, 19.21 and 24.8 for Standard, Penelope, Livermore and Geant4-DNA respectively). Cutoff energy considered for electrons and gamma photons affect the results in dose estimation for Auger electrons in Monte Carlo simulation.
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