细菌外多糖的合成与应用

IF 6.9 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current Opinion in Chemical Biology Pub Date : 2023-12-21 DOI:10.1016/j.cbpa.2023.102418

Gijs Ruijgrok, Dung-Yeh Wu, Herman S. Overkleeft, Jeroen D.C. Codée

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引用次数: 0

摘要

细菌在生成生物膜的过程中会产生并排出外多糖，以提供保护性环境。这些多糖通常以长度不一的异质聚合物形式生成，具有不同的取代模式。要获得这些多糖的明确片段，有机合成通常是首选方法，因为有机合成可以完全控制链的长度并安装预定的取代模式。本综述介绍了铜绿假单胞菌和金黄色葡萄球菌外多糖片段的几种最新合成方法，并说明了这些方法如何被用于研究生物合成酶和生成合成糖结合疫苗。

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Synthesis and application of bacterial exopolysaccharides

Exopolysaccharides are produced and excreted by bacteria in the generation of biofilms to provide a protective environment. These polysaccharides are generally generated as heterogeneous polymers of varying length, featuring diverse substitution patterns. To obtain well-defined fragments of these polysaccharides, organic synthesis often is the method of choice, as it allows for full control over chain length and the installation of a pre-determined substitution pattern. This review presents several recent syntheses of exopolysaccharide fragments of Pseudomonas aeruginosa and Staphylococcus aureus and illustrates how these have been used to study biosynthesis enzymes and generate synthetic glycoconjugate vaccines.

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来源期刊

Current Opinion in Chemical Biology 生物-生化与分子生物学

CiteScore

13.30

自引率

1.30%

发文量

113

审稿时长

74 days

期刊介绍： COCHBI (Current Opinion in Chemical Biology) is a systematic review journal designed to offer specialists a unique and educational platform. Its goal is to help professionals stay informed about the growing volume of information in the field of Chemical Biology through systematic reviews.